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    Fhl4 four and a half LIM domains 4 [ Mus musculus (house mouse) ]

    Gene ID: 14202, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Fhl4provided by MGI
    Official Full Name
    four and a half LIM domains 4provided by MGI
    Primary source
    MGI:MGI:1338765
    See related
    Ensembl:ENSMUSG00000050035 AllianceGenome:MGI:1338765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of mitotic cell cycle phase transition; regulation of membrane depolarization; and regulation of potassium ion transport. Predicted to be located in cytosol; nucleus; and plasma membrane. Is expressed in bladder; testis; and ureter. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 654.1) See more
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    Genomic context

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    Location:
    10 C1; 10 41.63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84932883..84938359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (85097019..85102495, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIC8 guanine nucleotide exchange factor B Neighboring gene predicted gene, 34633 Neighboring gene STARR-seq mESC enhancer starr_27436 Neighboring gene STARR-seq mESC enhancer starr_27437 Neighboring gene STARR-seq mESC enhancer starr_27438 Neighboring gene predicted gene, 51826 Neighboring gene transmembrane protein 263 Neighboring gene STARR-positive B cell enhancer ABC_E722 Neighboring gene mitochondrial transcription termination factor 2 Neighboring gene cryptochrome circadian regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The fourth member of the FHL family of LIM proteins is expressed exclusively in the testis. Morgan MJ, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049694
    2. The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle. Morgan MJ, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049693
    3. A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM. Fimia GM, et al. Mol Cell Biol, 2000 Nov. PMID 11046156, Free PMC Article
    4. The complexity of antisense transcription revealed by the study of developing male germ cells. Chan WY, et al. Genomics, 2006 Jun. PMID 16458478
    5. Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Chung YC, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20932939

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    four and a half LIM domains 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010214.4 → NP_034344.2  four and a half LIM domains 4

      See identical proteins and their annotated locations for NP_034344.2

      Status: VALIDATED

      Source sequence(s)
      AC122238, AK029585
      Consensus CDS
      CCDS24086.1
      UniProtKB/TrEMBL
      Q6P8P1, Q8CDC8, Q9DAH0
      Related
      ENSMUSP00000050054.7, ENSMUST00000059383.8
      Conserved Domains (4) summary
      cd09348
      Location:216 → 279
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:100 → 157
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:161 → 213
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:39 → 92
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      84932883..84938359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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