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    Fgf5 fibroblast growth factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 14176, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fgf5provided by MGI
    Official Full Name
    fibroblast growth factor 5provided by MGI
    Primary source
    MGI:MGI:95519
    See related
    Ensembl:ENSMUSG00000029337 AllianceGenome:MGI:95519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    go; Fgf-5; Fgf3a; HBGF-5; angora
    Summary
    This gene encodes a secreted protein that is a member of a family of heparin-binding growth factors. The encoded protein regulates cell proliferation, particularly the growth of hair follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E3; 5 47.77 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (98402108..98424892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (98254184..98277033)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A730035I17 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene PR domain containing 8 Neighboring gene STARR-seq mESC enhancer starr_13701 Neighboring gene cilia and flagella associated protein 299 Neighboring gene predicted gene, 34475 Neighboring gene microRNA 703

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells. Li Y, et al. Biochem Biophys Res Commun, 2022 Dec 17. PMID 36244113, Free PMC Article
    2. Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations. Takahashi R, et al. Int J Mol Sci, 2022 Oct 6. PMID 36233155, Free PMC Article
    3. Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice. Nakashima H, et al. Sci Rep, 2016 Oct 6. PMID 27708340, Free PMC Article
    4. Fibroblast growth factor-5 participates in the progression of hepatic fibrosis. Hanaka H, et al. Exp Anim, 2014. PMID 24521867, Free PMC Article
    5. Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair. Mizuno S, et al. Exp Anim, 2011. PMID 21512271

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
      Title: FGF5 alleviated acute lung injury via AKT signal pathway in endothelial cells.
    2. Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.
      Title: Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.
    3. SP1-induced lncRNA TUG1 regulates proliferation and apoptosis in islet cells of type 2 diabetes mellitus via the miR-188-3p/FGF5 axis.
      Title: SP1-induced lncRNA TUG1 regulates proliferation and apoptosis in islet cells of type 2 diabetes mellitus via the miR-188-3p/FGF5 axis.
    4. Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
      Title: Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.
    5. Etv5 can positively regulate primitive endoderm specification through regulating Gata6 and negatively regulate epiblast specification by inhibiting Fgf5 expression.
      Title: The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
    6. Recruited CD11b+ CD68+ Kupffer cells/Mphis may play an essential role in steatohepatitis and fibrosis in FGF5 null mice fed with a HFD. Recruitment and activation of bone marrow derived Mphis is the key factor to develop steatohepatitis from simple steatosis.
      Title: Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.
    7. It participates in the progression of hepatic fibrosis.
      Title: Fibroblast growth factor-5 participates in the progression of hepatic fibrosis.
    8. Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice
      Title: [Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice].
    9. A deletion of a 9.3-kb region in the Fgf5 gene showed insertion of a 498-bp early transposon element long terminal repeat. Results show that long hair mutation of moja/moja mice is caused by Fgf5 disruption mediated by retrotransposon insertion.
      Title: Retrotransposon-mediated Fgf5(go-Utr) mutant mice with long pelage hair.
    10. Fluctuations of BMP2 signaling pathway during hair cycles in skin with mutant genes we, wal and Fgf5(go).
      Title: Fluctuations of BMP signaling pathway during hair cycles in skin of mice with mutant genes we, wal and Fgf5(go).
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 5
    Names
    fibroblast growth factor 3a
    heparin-binding growth factor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277268.2 → NP_001264197.1  fibroblast growth factor 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001264197.1

      Status: VALIDATED

      Source sequence(s)
      AC125073
      Consensus CDS
      CCDS80344.1
      UniProtKB/Swiss-Prot
      P15656
      Related
      ENSMUSP00000142420.2, ENSMUST00000200059.2
      Conserved Domains (1) summary
      cl00060
      Location:85 → 114
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    2. NM_010203.6 → NP_034333.1  fibroblast growth factor 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034333.1

      Status: VALIDATED

      Source sequence(s)
      AC125073
      Consensus CDS
      CCDS19455.1
      UniProtKB/Swiss-Prot
      O88825, P15656
      UniProtKB/TrEMBL
      A0A7U3L698
      Related
      ENSMUSP00000031280.2, ENSMUST00000031280.2
      Conserved Domains (1) summary
      pfam00167
      Location:85 → 214
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      98402108..98424892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15656.1 GenPept UniProtKB/Swiss-Prot:P15656

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