Fgf2 fibroblast growth factor 2 [ Mus musculus (house mouse) ]

Gene ID: 14173, updated on 21-Apr-2024

Summary

Official Symbol: Fgf2provided by MGI
Official Full Name: fibroblast growth factor 2provided by MGI
Primary source: MGI:MGI:95516
See related: Ensembl:ENSMUSG00000037225 AllianceGenome:MGI:95516
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgfb; bFGF; Fgf-2; Fgf2a
Summary: Enables growth factor activity. Involved in stem cell development. Acts upstream of or within several processes, including animal organ development; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (fibroblast growth factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 4.1), ovary adult (RPKM 3.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 18.41 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (37402616..37464255)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (37348477..37410106)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice.
Title: A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice.
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Title: FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2.
Title: YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2.
Fibroblast Growth Factor 2 Is Produced By Renal Tubular Cells to Act as a Paracrine Factor in Maladaptive Kidney Repair After Cisplatin Nephrotoxicity.
Title: Fibroblast Growth Factor 2 Is Produced By Renal Tubular Cells to Act as a Paracrine Factor in Maladaptive Kidney Repair After Cisplatin Nephrotoxicity.
Evaluating the effect of basic fibroblast growth factor on the progression of NASH disease by inhibiting ceramide synthesis and ER stress-related pathways.
Title: Evaluating the effect of basic fibroblast growth factor on the progression of NASH disease by inhibiting ceramide synthesis and ER stress-related pathways.
Fibroblast growth factor 2 (FGF2) ameliorates the coagulation abnormalities in sepsis.
Title: Fibroblast growth factor 2 (FGF2) ameliorates the coagulation abnormalities in sepsis.
FGF2 isoforms play distinct roles in tubular epithelial-to-mesenchymal transition in diabetic nephropathy.
Title: FGF2 isoforms play distinct roles in tubular epithelial-to-mesenchymal transition in diabetic nephropathy.
FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis.
Title: FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis.
FGF2 is an endogenous regulator of alcohol reward and consumption.
Title: FGF2 is an endogenous regulator of alcohol reward and consumption.
FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models.
Title: FGF/FGFR Pathways in Multiple Sclerosis and in Its Disease Models.

Submit: New GeneRIF Correction See all GeneRIFs (289)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgf2 (e-PCR), detects polymorphism
- UniSTS:265487

Fgf2 (e-PCR), detects polymorphism
- UniSTS:507921

Fgf2 (e-PCR), detects polymorphism
- UniSTS:462627

Fgf2 (e-PCR), detects polymorphism
- UniSTS:273720

Fgf2 (e-PCR), detects polymorphism
- UniSTS:547900

Fgf2 (e-PCR), detects polymorphism
- UniSTS:464707

D3Nds34 (e-PCR), detects polymorphism
- UniSTS:142411

Fgf2 (e-PCR), detects polymorphism
- UniSTS:480339

D3Nds51 (e-PCR), detects polymorphism
- UniSTS:142426

Fgf2 (e-PCR), detects polymorphism
- UniSTS:265077

Fgf2 (e-PCR), detects polymorphism
- UniSTS:461975

Fgf2 (e-PCR), detects polymorphism
- UniSTS:258265

Fgf2 (e-PCR), detects polymorphism
- UniSTS:143089

Fgf2 (e-PCR), detects polymorphism
- UniSTS:266997

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor-receptor interaction	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angiogenesis involved in coronary vascular morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in chondroblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within corticotropin hormone secreting cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in embryo development ending in birth or egg hatching	ISO Inferred from Sequence Orthology more info
acts_upstream_of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth factor dependent regulation of skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of inner ear auditory receptor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of lymphatic endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mammary gland epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuroepithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within organ induction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in paracrine signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell fate specification	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of inner ear auditory receptor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of neuroepithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of retinal cell programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of stem cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within substantia nigra development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 2

Names: HBGF-2; basic fibroblast growth factor; fibroblast growth factor 2a; heparin-binding growth factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008006.2 → NP_032032.1 fibroblast growth factor 2

See identical proteins and their annotated locations for NP_032032.1

Status: VALIDATED

Source sequence(s)

AF065904, AL669927, BY730691, CJ098597

Consensus CDS

CCDS17320.1

UniProtKB/Swiss-Prot

P15655

UniProtKB/TrEMBL

Q541T2, Q925A3

Related

ENSMUSP00000143094.2, ENSMUST00000200585.5

Conserved Domains (1) summary

pfam00167
Location:28 → 148

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

37402616..37464255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162894.1 → XP_036018787.1 fibroblast growth factor 2 isoform X2

Conserved Domains (1) summary

cl00060
Location:28 → 59

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
XM_006535399.5 → XP_006535462.1 fibroblast growth factor 2 isoform X1

See identical proteins and their annotated locations for XP_006535462.1

UniProtKB/TrEMBL

Q925A3

Conserved Domains (1) summary

pfam00167
Location:27 → 159

FGF; Fibroblast growth factor