Fgf18 fibroblast growth factor 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf18provided by MGI
Official Full Name: fibroblast growth factor 18provided by MGI
Primary source: MGI:MGI:1277980
See related: Ensembl:ENSMUSG00000057967 AllianceGenome:MGI:1277980
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgf6a; FGF-18; D130055P09Rik
Summary: Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of chondrocyte differentiation; positive regulation of signal transduction; and skeletal system development. Predicted to be located in nucleolus. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and skeleton. Orthologous to human FGF18 (fibroblast growth factor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 4.9), lung adult (RPKM 2.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 19.21 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (33066970..33097400, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (33116970..33147400, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-kappaB pathway.
Title: FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway.
Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis.
Title: Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis.
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Title: FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
Title: TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.
Tissue-specific analysis of Fgf18 gene function in palate development.
Title: Tissue-specific analysis of Fgf18 gene function in palate development.
Fibroblast growth factor 18 alleviates hyperoxia-induced lung injury in mice by adjusting oxidative stress and inflammation.
Title: Fibroblast growth factor 18 alleviates hyperoxia-induced lung injury in mice by adjusting oxidative stress and inflammation.
The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Title: The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall.
Using a novel Fgf18:CreERT2 allele to lineage trace alveolar myofibroblast, it is demonstrated that most alveolar myofibroblast are developmentally cleared during alveologenesis.
Title: Identification of a FGF18-expressing alveolar myofibroblast that is developmentally cleared during alveologenesis.
Study found that Fgf18 mRNA was one of the spinal motor neurons (SMNs)-specific FGFs in adult mice. Fgf18 mRNA was expressed in the spinal cord, and to a lesser extent in the diaphragm, in mouse embryos. In C2C12 myotubes, FGF18 enhanced AChR clustering. These data propose that FGF18 plays a pivotal role in AChR clustering and NMJ formation in mouse embryogenesis.
Title: Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.
Elevation of FGF signaling, mainly due to increased Fgf18 expression upon inactivation of Evc2 in the perichondrium, critically contributes to the pathogenesis of limb dwarfism. The limb dwarfism phenotype is partially rescued by inactivation of one allele of Fgf18 in the Evc2 mutant mice
Title: Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

General gene information

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Markers

Fgf18 (e-PCR), detects polymorphism
- UniSTS:507920

Fgf18 (e-PCR), detects polymorphism
- UniSTS:546577

Fgf18 (e-PCR), detects polymorphism
- UniSTS:516629

NoName (e-PCR)
- UniSTS:489052

AF075291 (e-PCR)
- UniSTS:163494

Fgf18 (e-PCR), detects polymorphism
- UniSTS:258264

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intramembranous ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor 18

Names: fibroblast growth factor 6a; zFGF5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008005.2 → NP_032031.1 fibroblast growth factor 18 precursor

See identical proteins and their annotated locations for NP_032031.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

AF211187, AL732390, AL772409

Consensus CDS

CCDS24531.1

UniProtKB/Swiss-Prot

O89101

UniProtKB/TrEMBL

A0A7U3JW51

Related

ENSMUSP00000020507.8, ENSMUST00000020507.8

Conserved Domains (1) summary

pfam00167
Location:53 → 175

FGF; Fibroblast growth factor

RNA

NR_102395.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate donor splice site in the 5' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK078245, AL732390, AL772409