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    Fgf13 fibroblast growth factor 13 [ Mus musculus (house mouse) ]

    Gene ID: 14168, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fgf13provided by MGI
    Official Full Name
    fibroblast growth factor 13provided by MGI
    Primary source
    MGI:MGI:109178
    See related
    Ensembl:ENSMUSG00000031137 AllianceGenome:MGI:109178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fhf2; Fgf1c
    Summary
    Enables sodium channel regulator activity; transmembrane transporter binding activity; and tubulin binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of cardiac muscle cell action potential involved in regulation of contraction. Located in several cellular components, including growth cone; intercalated disc; and lateral plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Used to study intellectual disability. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 22.7), frontal lobe adult (RPKM 16.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A6; X 33.31 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (58107499..58630932, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (59062139..59585572, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene MAGE family member A13 Neighboring gene microRNA 504 Neighboring gene predicted gene, 26487 Neighboring gene histidyl-tRNA synthetase 2, mitochondrial (putative) pseudogene Neighboring gene predicted gene, 39518 Neighboring gene STARR-seq mESC enhancer starr_47232 Neighboring gene STARR-seq mESC enhancer starr_47233 Neighboring gene STARR-seq mESC enhancer starr_47234 Neighboring gene STARR-seq mESC enhancer starr_47235 Neighboring gene predicted gene, 36631 Neighboring gene STARR-seq mESC enhancer starr_47236 Neighboring gene synaptophysin-like protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy. Shen KF, et al. Cereb Cortex, 2022 Nov 21. PMID 35195262
    2. Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice. Yu Y, et al. Front Cell Neurosci, 2021. PMID 34220452, Free PMC Article
    3. Fibroblast growth factor 13 stabilizes microtubules to promote Na(+) channel function in nociceptive DRG neurons and modulates inflammatory pain. Wang Q, et al. J Adv Res, 2021 Jul. PMID 34194835, Free PMC Article
    4. FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with Na(V)1.7. Dong F, et al. J Neurosci, 2020 Dec 9. PMID 33172979, Free PMC Article
    5. Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart. Park DS, et al. Circ Res, 2020 Dec 4. PMID 32962518, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhanced sodium channel inactivation by temperature and FHF2 deficiency blocks heat nociception.
      Title: Enhanced sodium channel inactivation by temperature and FHF2 deficiency blocks heat nociception.
    2. Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy.
      Title: Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy.
    3. 5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
      Title: 5'-UTR SNP of FGF13 causes translational defect and intellectual disability.
    4. Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.
      Title: Ionic Mechanisms of Impulse Propagation Failure in the FHF2-Deficient Heart.
    5. FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with NaV1.7.
      Title: FGF13 Is Required for Histamine-Induced Itch Sensation by Interaction with Na(V)1.7.
    6. E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.
      Title: E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration.
    7. Heterozygous Fgf13 knockouts fed normal chow.
      Title: Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity.
    8. High FGF13 expression is associated with glioma cell invasion.
      Title: Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion.
    9. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors
      Title: Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors.
    10. FHF2 has an essential role in dictating myocardial excitability and conduction that safeguards against temperature-sensitive conduction failure
      Title: Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within branching morphogenesis of a nerve IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebral cortex cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in establishment of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of neuroblast polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inhibitory synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor 13
    Names
    fibroblast growth factor 1c
    fibroblast growth factor homologous factor 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290414.1 → NP_001277343.1  fibroblast growth factor 13 isoform 2

      See identical proteins and their annotated locations for NP_001277343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1. Variants 2 and 5-8 all encode the same isoform (2).
      Source sequence(s)
      AL669891, AL670091, AL672247, AL713968
      Conserved Domains (1) summary
      smart00442
      Location:77 → 207
      FGF; Acidic and basic fibroblast growth factor family

    2. NM_001290415.1 → NP_001277344.1  fibroblast growth factor 13 isoform 3

      See identical proteins and their annotated locations for NP_001277344.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK141848, BC018238, CD776909, CJ064772
      Consensus CDS
      CCDS72383.1
      UniProtKB/TrEMBL
      B1AU20
      Related
      ENSMUSP00000113206.2, ENSMUST00000119306.2
      Conserved Domains (1) summary
      smart00442
      Location:14 → 144
      FGF; Acidic and basic fibroblast growth factor family

    3. NM_001356335.1 → NP_001343264.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968
      UniProtKB/TrEMBL
      B1AU20
      Conserved Domains (1) summary
      smart00442
      Location:21 → 151
      FGF; Acidic and basic fibroblast growth factor family

    4. NM_001411971.1 → NP_001398900.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968

    5. NM_001411972.1 → NP_001398901.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968

    6. NM_001411973.1 → NP_001398902.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968

    7. NM_001425598.1 → NP_001412527.1  fibroblast growth factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL672247, AL713968

    8. NM_001425599.1 → NP_001412528.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968

    9. NM_001425600.1 → NP_001412529.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968

    10. NM_001425601.1 → NP_001412530.1  fibroblast growth factor 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL669891, AL713968

    11. NM_010200.3 → NP_034330.2  fibroblast growth factor 13 isoform 1

      See identical proteins and their annotated locations for NP_034330.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC018238, CD776909
      Consensus CDS
      CCDS30157.1
      UniProtKB/Swiss-Prot
      B1AU21, O35338, P70377, Q3UR31, Q8VCY9, Q9JLA5
      UniProtKB/TrEMBL
      A0A7U3JW69
      Related
      ENSMUSP00000033473.6, ENSMUST00000033473.12
      Conserved Domains (1) summary
      smart00442
      Location:67 → 197
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      58107499..58630932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527799.3 → XP_006527862.1  fibroblast growth factor 13 isoform X3

      UniProtKB/TrEMBL
      B1AU20
      Conserved Domains (1) summary
      smart00442
      Location:11 → 141
      FGF; Acidic and basic fibroblast growth factor family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70377.2 GenPept UniProtKB/Swiss-Prot:P70377

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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