Lgr5 leucine rich repeat containing G protein coupled receptor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgr5provided by MGI
Official Full Name: leucine rich repeat containing G protein coupled receptor 5provided by MGI
Primary source: MGI:MGI:1341817
See related: Ensembl:ENSMUSG00000020140 AllianceGenome:MGI:1341817
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FEX; Gpr49
Summary: The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
Expression: Broad expression in frontal lobe adult (RPKM 8.3), limb E14.5 (RPKM 3.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 63.51 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (115286219..115423685, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (115450314..115587780, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
Title: Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease.
Study on Lgr5 expression in pancreas tissues and organoids by lineage tracing.
Title: Study on Lgr5 expression in pancreas tissues and organoids by lineage tracing.
ANKRD22 Drives Rapid Proliferation of Lgr5(+) Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.
Title: ANKRD22 Drives Rapid Proliferation of Lgr5(+) Cells and Acts as a Promising Therapeutic Target in Gastric Mucosal Injury.
IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Title: IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
PTEN-mediated AKT/beta-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes.
Title: PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes.
Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.
Title: Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation.
alphaSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
Title: αSMA(+) fibroblasts suppress Lgr5(+) cancer stem cells and restrain colorectal cancer progression.
Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.
Title: Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.
Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
Title: Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
Interleukin-10 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of Wnt and notch signaling.
Title: Interleukin-10 expands transit-amplifying cells while depleting Lgr5(+) stem cells via inhibition of Wnt and notch signaling.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Endonuclease-mediated (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

07.MMHAP17FC1.seq (e-PCR)
- UniSTS:122880

Lgr5 (e-PCR), detects polymorphism
- UniSTS:526861

Lgr5 (e-PCR), detects polymorphism
- UniSTS:526862

NoName (e-PCR)
- UniSTS:546842

Lgr5 (e-PCR), detects polymorphism
- UniSTS:546842

AF110818 (e-PCR)
- UniSTS:180121

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hair follicle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within oocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 5

Names: G protein-coupled receptor 49; follicle expressed hormone; orphan G-protein coupled receptor FEX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010195.2 → NP_034325.2 leucine-rich repeat-containing G-protein coupled receptor 5 precursor

See identical proteins and their annotated locations for NP_034325.2

Status: REVIEWED

Source sequence(s)

AK132387, BM935530

Consensus CDS

CCDS24180.1

UniProtKB/Swiss-Prot

Q3V1L2, Q9Z1P4

UniProtKB/TrEMBL

G3UXX4

Related

ENSMUSP00000020350.9, ENSMUST00000020350.15

Conserved Domains (6) summary

smart00013
Location:33 → 70

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:88 → 386

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:354 → 375

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:68 → 91

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:575 → 820

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat