Fasl Fas ligand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Faslprovided by MGI
Official Full Name: Fas ligandprovided by MGI
Primary source: MGI:MGI:99255
See related: Ensembl:ENSMUSG00000000817 AllianceGenome:MGI:99255
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gld; CD178; CD95L; Fas-L; Faslg; CD95-L; Tnfsf6; Tnlg1a; APT1LG1
Summary: Predicted to enable death receptor binding activity and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 69.95 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (161608260..161616064, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (161780691..161788495, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ambivalent role of FasL in murine acute graft-versus-host-disease.
Title: Ambivalent role of FasL in murine acute graft-versus-host-disease.
CRISPR/Cas9-mediated abrogation of CD95L/CD95 signaling-induced glioma cell growth and immunosuppression increases survival in murine glioma models.
Title: CRISPR/Cas9-mediated abrogation of CD95L/CD95 signaling-induced glioma cell growth and immunosuppression increases survival in murine glioma models.
FasL is a catabolic factor in alveolar bone homeostasis.
Title: FasL is a catabolic factor in alveolar bone homeostasis.
E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.
Title: E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.
Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation.
Title: Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation.
FasL Is Required for Osseous Healing in Extraction Sockets in Mice.
Title: FasL Is Required for Osseous Healing in Extraction Sockets in Mice.
Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens.
Title: Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens.
LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
Title: LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8(+) T Cells During Ischemic Stroke.
Title: FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8(+) T Cells During Ischemic Stroke.
The cleft palate candidate gene BAG6 supports FoxO1 acetylation topromote FasL-mediated apoptosis during palate fusion.
Title: The cleft palate candidate gene BAG6 supports FoxO1 acetylation to promote FasL-mediated apoptosis during palate fusion.

Submit: New GeneRIF Correction See all GeneRIFs (318)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Targeted (7) 1 citation
Chemically induced (ENU) (2)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Ins1 (e-PCR), detects polymorphism
- UniSTS:233989

PMC86001P1 (e-PCR)
- UniSTS:273502

PMC86001P2 (e-PCR)
- UniSTS:273503

U06948 (e-PCR)
- UniSTS:158872

U06948 (e-PCR)
- UniSTS:125655

Tnfsf6 (e-PCR), detects polymorphism
- UniSTS:143073

Tnfsf6 (e-PCR), detects polymorphism
- UniSTS:143074

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endosomal lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylserine exposure on apoptotic cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 6

Names: CD95 ligand; Fas antigen ligand; Fas ligand (TNF superfamily, member 6); generalized lymphoproliferative disease; tumor necrosis factor ligand 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001205243.1 → NP_001192172.1 tumor necrosis factor ligand superfamily member 6 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC164414, AF288572

UniProtKB/TrEMBL

Q99PH8
NM_010177.4 → NP_034307.1 tumor necrosis factor ligand superfamily member 6 isoform 1

See identical proteins and their annotated locations for NP_034307.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK040139

Consensus CDS

CCDS15418.1

UniProtKB/Swiss-Prot

P41047, Q61217, Q9R1F2

UniProtKB/TrEMBL

Q544E9, Q7TMV9

Related

ENSMUSP00000000834.3, ENSMUST00000000834.4

Conserved Domains (1) summary

cd00184
Location:144 → 277

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...