Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc17a6provided by MGI
Official Full Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6provided by MGI
Primary source: MGI:MGI:2156052
See related: Ensembl:ENSMUSG00000030500 AllianceGenome:MGI:2156052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DNPI; VGLUT2; 2900073D12Rik
Summary: Enables L-glutamate transmembrane transporter activity. Involved in hyaloid vascular plexus regression. Acts upstream of or within neurotransmitter uptake. Located in synaptic vesicle. Is expressed in several structures, including cranial ganglion; nervous system; sensory organ; tail mesenchyme; and testis. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 12.2), whole brain E14.5 (RPKM 12.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 32.78 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (51271578..51320874)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (51621830..51671126)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VGLUT2 and APP family: unraveling the neurobiochemical mechanisms of neurostimulation therapy to STZ-induced diabetes and neuropathy.
Title: VGLUT2 and APP family: unraveling the neurobiochemical mechanisms of neurostimulation therapy to STZ-induced diabetes and neuropathy.
Increase of vesicular glutamate transporter 2 co-expression in the deep cerebellar nuclei related to skilled reach learning.
Title: Increase of vesicular glutamate transporter 2 co-expression in the deep cerebellar nuclei related to skilled reach learning.
Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice.
Title: Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice.
Activation of VGluT2-expressing neurons in the bed nuclei of the stria terminalis produces mouse manic-like behaviors.
Title: Activation of VGluT2-expressing neurons in the bed nuclei of the stria terminalis produces mouse manic-like behaviors.
Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections.
Title: Posterodorsal Medial Amygdala Regulation of Female Social Behavior: GABA versus Glutamate Projections.
Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice.
Title: Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice.
Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2.
Title: Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2.
VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation.
Title: VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation.
Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis.
Title: Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis.
Results demonstrate that most mesopontine cholinergic neurons may transiently express VGLUT2, but that a large majority of parabigeminal nucleus neurons retain VGLUT2 expression throughout adulthood, and support a growing body of literature indicating that distinct cholinergic populations have differing potential for GABA or glutamate co-release.
Title: Differential Expression of VGLUT2 in Mouse Mesopontine Cholinergic Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (17) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc17a6 (e-PCR), detects polymorphism
- UniSTS:498768

Slc17a6 (e-PCR), detects polymorphism
- UniSTS:547008

D7Mit85 (e-PCR), detects polymorphism
- UniSTS:116718

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate uniporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate uniporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-glutamate import	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
involved_in hyaloid vascular plexus regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter loading into synaptic vesicle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurotransmitter uptake	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structure or activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium-dependent phosphate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium-dependent phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in excitatory synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in pericellular basket	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vesicular glutamate transporter 2

Names: differentiation-associated BNPI; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (vesicular glutamate transporter), member 6; solute carrier family 17 member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355150.1 → NP_001342079.1 vesicular glutamate transporter 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC113306, AC163335

UniProtKB/Swiss-Prot

Q8BLE7, Q920B7

Conserved Domains (1) summary

cl27298
Location:1 → 436

UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]
NM_080853.3 → NP_543129.3 vesicular glutamate transporter 2 isoform 1

See identical proteins and their annotated locations for NP_543129.3

Status: VALIDATED

Source sequence(s)

AF324864, BB304814, BC038375, CB519039, CD578992

Consensus CDS

CCDS39969.1

UniProtKB/Swiss-Prot

Q8BLE7, Q920B7

UniProtKB/TrEMBL

A0A0R4J0A6

Related

ENSMUSP00000032710.6, ENSMUST00000032710.7

Conserved Domains (2) summary

cd06174
Location:75 → 498

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:70 → 511

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

51271578..51320874

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540601.5 → XP_006540664.1 vesicular glutamate transporter 2 isoform X1

UniProtKB/Swiss-Prot

Q8BLE7, Q920B7

Conserved Domains (1) summary

cd17382
Location:47 → 471

MFS_SLC17A6_7_8_VGluT; Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters