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    Slc7a12 solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 [ Mus musculus (house mouse) ]

    Gene ID: 140918, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Slc7a12provided by MGI
    Official Full Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 12provided by MGI
    Primary source
    MGI:MGI:2156159
    See related
    Ensembl:ENSMUSG00000039710 AllianceGenome:MGI:2156159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XAT1; Asc-2; XAT-1
    Summary
    Enables amino acid transmembrane transporter activity. Acts upstream of or within amino acid transport. Located in cytoplasm and plasma membrane. Orthologous to human SLC7A13 (solute carrier family 7 member 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward kidney adult (RPKM 34.7) See more
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    Genomic context

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    Location:
    3 A1; 3 3.05 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14545757..14570879)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14480697..14505819)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06997 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member pseudogene Neighboring gene STARR-seq mESC enhancer starr_06998 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene leucine rich repeat and coiled-coil domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. Chairoungdua A, et al. J Biol Chem, 2001 Dec 28. PMID 11591708
    2. Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2. Blondeau JP. Gene, 2002 Mar 20. PMID 11943479
    3. Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Haller M, et al. Proc Natl Acad Sci U S A, 2017 May 9. PMID 28439006, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 7 member 12
    Names
    Asc-2,asc-type amino acid transporter 2
    X-amino acid transporter 1
    asc-type amino acid transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080852.3 → NP_543128.1  solute carrier family 7 member 12

      See identical proteins and their annotated locations for NP_543128.1

      Status: VALIDATED

      Source sequence(s)
      AC131593, AC163676
      Consensus CDS
      CCDS17246.1
      UniProtKB/Swiss-Prot
      Q8R2J1, Q8VIE6
      Related
      ENSMUSP00000038574.8, ENSMUST00000037321.8
      Conserved Domains (1) summary
      pfam13520
      Location:7 → 412
      AA_permease_2; Amino acid permease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      14545757..14570879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530052.2 → XP_006530115.1  solute carrier family 7 member 12 isoform X1

      Conserved Domains (1) summary
      TIGR00911
      Location:2 → 377
      2A0308; L-type amino acid transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VIE6.1 GenPept UniProtKB/Swiss-Prot:Q8VIE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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