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    Dclre1b DNA cross-link repair 1B [ Mus musculus (house mouse) ]

    Gene ID: 140917, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dclre1bprovided by MGI
    Official Full Name
    DNA cross-link repair 1Bprovided by MGI
    Primary source
    MGI:MGI:2156057
    See related
    Ensembl:ENSMUSG00000027845 AllianceGenome:MGI:2156057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SNMIB; Apollo; mSNM1B
    Summary
    Enables 5'-3' exonuclease activity. Involved in protection from non-homologous end joining at telomere; telomeric 3' overhang formation; and telomeric loop formation. Located in chromosome, telomeric region. Is expressed in brain. Orthologous to human DCLRE1B (DNA cross-link repair 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 4.1), liver E14 (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.2; 3 45.52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103707921..103716703, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103800605..103809387, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103542020-103542203 Neighboring gene STARR-positive B cell enhancer ABC_E6093 Neighboring gene olfactomedin-like 3 Neighboring gene homeodomain interacting protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103577942-103578125 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103581922-103582188 Neighboring gene predicted gene 15886 Neighboring gene STARR-positive B cell enhancer ABC_E11207 Neighboring gene predicted gene 15471 Neighboring gene adaptor-related protein complex AP-4, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E7934 Neighboring gene STARR-seq mESC enhancer starr_08603 Neighboring gene BCLl2-like 15 Neighboring gene STARR-positive B cell enhancer ABC_E3458 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103663204-103663387 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103664081-103664275 Neighboring gene STARR-positive B cell enhancer ABC_E6094 Neighboring gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Neighboring gene STARR-positive B cell enhancer ABC_E2090 Neighboring gene STARR-seq mESC enhancer starr_08604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair. Lam YC, et al. EMBO J, 2010 Jul 7. PMID 20551906, Free PMC Article
    2. Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST. Wu P, et al. Cell, 2012 Jul 6. PMID 22748632, Free PMC Article
    3. The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development. Akhter S, et al. Aging Cell, 2010 Dec. PMID 20854421, Free PMC Article
    4. Apollo contributes to G overhang maintenance and protects leading-end telomeres. Wu P, et al. Mol Cell, 2010 Aug 27. PMID 20619712, Free PMC Article
    5. SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint. Akhter S, et al. Biochem Biophys Res Commun, 2008 Dec 5. PMID 18848520, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study documents the combinatorial action of Apollo, POT1b, CST, and the 5' exonuclease Exo1 in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
      Title: Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
    2. The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development
      Title: The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.
    3. TRF2-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM signaling, and protecting leading-end telomeres from fusion.
      Title: Apollo contributes to G overhang maintenance and protects leading-end telomeres.
    4. Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
      Title: SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 5'-3' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-lactamase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protection from non-homologous end joining at telomere IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protection from non-homologous end joining at telomere ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere capping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomeric 3' overhang formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomeric loop formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5' exonuclease Apollo
    Names
    DNA cross-link repair 1B protein
    DNA cross-link repair 1B, PSO2 homolog
    SNM1 homolog B
    beta-lactamase MBLAC2
    NP_001020483.1
    NP_598626.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025312.1 → NP_001020483.1  5' exonuclease Apollo isoform b

      See identical proteins and their annotated locations for NP_001020483.1

      Status: VALIDATED

      Source sequence(s)
      BC067017, BQ559794, CA317555
      Consensus CDS
      CCDS17695.1
      UniProtKB/Swiss-Prot
      Q8C7W7
      Related
      ENSMUSP00000067695.7, ENSMUST00000063502.13
      Conserved Domains (3) summary
      cd11662
      Location:366 → 398
      apollo_TRF2_binding; TRF2-binding region of apollo and similar proteins
      pfam07522
      Location:90 → 172
      DRMBL; DNA repair metallo-beta-lactamase
      cl23716
      Location:1 → 25
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. NM_133865.2 → NP_598626.2  5' exonuclease Apollo isoform a

      See identical proteins and their annotated locations for NP_598626.2

      Status: VALIDATED

      Source sequence(s)
      AK049115, AK084347, BC067017, CA548899
      Consensus CDS
      CCDS17694.1
      UniProtKB/Swiss-Prot
      A0JLW2, B0V3N9, B0V3P0, Q3U4P2, Q3UUC7, Q3UV92, Q6NXL4, Q8BN95, Q8BQS8, Q8C7W7, Q921S0
      Related
      ENSMUSP00000029435.9, ENSMUST00000029435.15
      Conserved Domains (3) summary
      cd11662
      Location:492 → 524
      apollo_TRF2_binding; TRF2-binding region of apollo and similar proteins
      pfam07522
      Location:216 → 298
      DRMBL; DNA repair metallo-beta-lactamase
      cd16273
      Location:6 → 151
      SNM1A-1C-like_MBL-fold; SNM1A , artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      103707921..103716703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C7W7.2 GenPept UniProtKB/Swiss-Prot:Q8C7W7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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