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    Caln1 calneuron 1 [ Mus musculus (house mouse) ]

    Gene ID: 140904, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Caln1provided by MGI
    Official Full Name
    calneuron 1provided by MGI
    Primary source
    MGI:MGI:2155987
    See related
    Ensembl:ENSMUSG00000060371 AllianceGenome:MGI:2155987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cabp8; MNCb-0849; 9630012C17Rik
    Summary
    Predicted to enable calcium ion binding activity. Located in trans-Golgi network membrane. Is expressed in central nervous system and retina. Orthologous to human CALN1 (calneuron 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 19.5), cortex adult (RPKM 8.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G1.3- G2; 5 69.29 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130398245..130876253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130369404..130846325)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:130730118-130730418 Neighboring gene STARR-positive B cell enhancer ABC_E234 Neighboring gene STARR-positive B cell enhancer ABC_E279 Neighboring gene STARR-seq mESC enhancer starr_14473 Neighboring gene RIKEN cDNA A330070K13 gene Neighboring gene SBDS ribosome maturation factor Neighboring gene STARR-seq mESC enhancer starr_14474 Neighboring gene tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_14475 Neighboring gene STARR-seq mESC enhancer starr_14476 Neighboring gene predicted gene, 40336 Neighboring gene STARR-seq mESC enhancer starr_14477 Neighboring gene STARR-seq mESC enhancer starr_14478 Neighboring gene predicted gene, 40337 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 17 Neighboring gene STARR-seq mESC enhancer starr_14479 Neighboring gene predicted gene, 40338

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Haeseleer F, et al. Adv Exp Med Biol, 2002. PMID 12596929
    2. Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily. Wu YQ, et al. Mol Genet Metab, 2001 Apr. PMID 11286509
    3. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. McCue HV, et al. Biochem Biophys Res Commun, 2009 Mar 20. PMID 19338761, Free PMC Article
    4. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Pereira JD, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20798045, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding protein 8
    Names
    calneuron I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021371.2 → NP_067346.1  calcium-binding protein 8 isoform b

      See identical proteins and their annotated locations for NP_067346.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when compared to isoform 1.
      Source sequence(s)
      BC058963, BY274079
      Consensus CDS
      CCDS19714.1
      UniProtKB/TrEMBL
      Q542R1, Q8CBJ9
      Related
      ENSMUSP00000106919.3, ENSMUST00000111288.4
      Conserved Domains (1) summary
      PTZ00184
      Location:32 → 142
      PTZ00184; calmodulin; Provisional

    2. NM_181045.2 → NP_851388.1  calcium-binding protein 8 isoform a

      See identical proteins and their annotated locations for NP_851388.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AC113029, AC120437, AC142405, AC156620
      Consensus CDS
      CCDS51656.1
      UniProtKB/Swiss-Prot
      F8WHE1, Q9JJG7
      UniProtKB/TrEMBL
      Q8CBJ9
      Related
      ENSMUSP00000083193.4, ENSMUST00000086029.10
      Conserved Domains (3) summary
      cd00051
      Location:82 → 143
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd15899
      Location:82 → 109
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:65 → 189
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      130398245..130876253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164786.1 → XP_036020679.1  calcium-binding protein 8 isoform X4

      UniProtKB/Swiss-Prot
      F8WHE1, Q9JJG7
      UniProtKB/TrEMBL
      Q8CBJ9
      Conserved Domains (3) summary
      cd00051
      Location:82 → 143
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd15899
      Location:82 → 109
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:65 → 189
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

    2. XM_006504369.4 → XP_006504432.1  calcium-binding protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006504432.1

      UniProtKB/TrEMBL
      Q8CBJ9
      Conserved Domains (1) summary
      PTZ00184
      Location:84 → 194
      PTZ00184; calmodulin; Provisional

    3. XM_006504367.4 → XP_006504430.1  calcium-binding protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006504430.1

      UniProtKB/TrEMBL
      Q8CBJ9
      Conserved Domains (1) summary
      PTZ00184
      Location:84 → 194
      PTZ00184; calmodulin; Provisional

    4. XM_006504372.5 → XP_006504435.1  calcium-binding protein 8 isoform X4

      See identical proteins and their annotated locations for XP_006504435.1

      UniProtKB/Swiss-Prot
      F8WHE1, Q9JJG7
      UniProtKB/TrEMBL
      Q8CBJ9
      Conserved Domains (3) summary
      cd00051
      Location:82 → 143
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd15899
      Location:82 → 109
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:65 → 189
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

    5. XM_006504368.5 → XP_006504431.1  calcium-binding protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006504431.1

      UniProtKB/TrEMBL
      Q8CBJ9
      Conserved Domains (1) summary
      PTZ00184
      Location:84 → 194
      PTZ00184; calmodulin; Provisional

    6. XM_036164784.1 → XP_036020677.1  calcium-binding protein 8 isoform X2

      UniProtKB/TrEMBL
      Q8CBJ9
      Conserved Domains (1) summary
      PTZ00184
      Location:84 → 194
      PTZ00184; calmodulin; Provisional

    7. XM_006504374.2 → XP_006504437.1  calcium-binding protein 8 isoform X5

      See identical proteins and their annotated locations for XP_006504437.1

      UniProtKB/TrEMBL
      Q542R1, Q8CBJ9
      Conserved Domains (1) summary
      PTZ00184
      Location:32 → 142
      PTZ00184; calmodulin; Provisional

    8. XM_006504373.3 → XP_006504436.1  calcium-binding protein 8 isoform X5

      See identical proteins and their annotated locations for XP_006504436.1

      UniProtKB/TrEMBL
      Q542R1, Q8CBJ9
      Related
      ENSMUSP00000106918.2, ENSMUST00000111287.8
      Conserved Domains (1) summary
      PTZ00184
      Location:32 → 142
      PTZ00184; calmodulin; Provisional

    9. XM_006504366.4 → XP_006504429.3  calcium-binding protein 8 isoform X1

      Conserved Domains (1) summary
      PTZ00184
      Location:87 → 197
      PTZ00184; calmodulin; Provisional

    10. XM_036164785.1 → XP_036020678.1  calcium-binding protein 8 isoform X3

      UniProtKB/TrEMBL
      Q8CBJ9
      Conserved Domains (1) summary
      PTZ00184
      Location:84 → 194
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJG7.2 GenPept UniProtKB/Swiss-Prot:Q9JJG7

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