Fabp2 fatty acid binding protein 2, intestinal [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fabp2provided by MGI
Official Full Name: fatty acid binding protein 2, intestinalprovided by MGI
Primary source: MGI:MGI:95478
See related: Ensembl:ENSMUSG00000023057 AllianceGenome:MGI:95478
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fabpi; I-FABP
Summary: The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within enterocytes, possibly to sense lipids as part of energy homeostasis. In humans polymorphisms are associated with increased fat oxidation and insulin resistance. In mice deficiency of this gene alters body weight in a gender-specific manner and causes hyperinsulinemia. [provided by RefSeq, Jan 2013]
Expression: Biased expression in large intestine adult (RPKM 347.4), small intestine adult (RPKM 41.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 53.74 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (122688721..122693155)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (122895072..122899506)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FABP2 is Involved in Intestinal alpha-Synuclein Pathologies.
Title: FABP2 is Involved in Intestinal α-Synuclein Pathologies.
The proximal intestinal Fatty Acid-Binding Proteins liver FABP (LFABP) and intestinal FABP (IFABP) differentially modulate whole body energy homeostasis but are not centrally involved in net dietary lipid absorption: Studies of the LFABP/IFABP double knockout mouse.
Title: The proximal intestinal Fatty Acid-Binding Proteins liver FABP (LFABP) and intestinal FABP (IFABP) differentially modulate whole body energy homeostasis but are not centrally involved in net dietary lipid absorption: Studies of the LFABP/IFABP double knockout mouse.
Two fatty acid-binding proteins expressed in the intestine interact differently with endocannabinoids.
Title: Two fatty acid-binding proteins expressed in the intestine interact differently with endocannabinoids.
The ablation of IFABP, coupled with high-fat feeding, leads to changes in gut motility and morphology, which likely contribute to the relatively leaner phenotype occurring at the whole-body level.
Title: Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice.
This direct comparison provides evidence that LFABP and IFABP have distinct roles in intestinal lipid metabolism; differential intracellular functions in intestine and in liver
Title: Direct comparison of mice null for liver or intestinal fatty acid-binding proteins reveals highly divergent phenotypic responses to high fat feeding.
detected the common as well as sex-differential pathways that are modified due to the loss of Fabp2. These findings suggest that the pathways involved in nutrient and xenobiotic metabolism in the intestine are regulated by sex-specific mechanisms
Title: Visualization of sex-dimorphic changes in the intestinal transcriptome of Fabp2 gene-ablated mice.
loss of I-FABP renders male mice sensitive to high fat diet-induced fatty liver, and this effect is independent of hepatic L-FABP
Title: Loss of intestinal fatty acid binding protein increases the susceptibility of male mice to high fat diet-induced fatty liver.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Fabp2 (e-PCR), detects polymorphism
- UniSTS:158729

M65034 (e-PCR)
- UniSTS:124974

Fabp2 (e-PCR), detects polymorphism
- UniSTS:143063

Fabp2 (e-PCR), detects polymorphism
- UniSTS:495835

D3Mit108 (e-PCR), detects polymorphism
- UniSTS:129509

D3Mit108.1 (e-PCR), detects polymorphism
- UniSTS:129510

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal lipid absorption	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical cortex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fatty acid-binding protein, intestinal

Names: intestinal fatty acid binding protein 2; intestinal-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.