Rem2 rad and gem related GTP binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rem2provided by MGI
Official Full Name: rad and gem related GTP binding protein 2provided by MGI
Primary source: MGI:MGI:2155260
See related: Ensembl:ENSMUSG00000022176 AllianceGenome:MGI:2155260
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable GTP binding activity; GTPase activity; and calcium channel regulator activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; epithelium; and limb. Orthologous to human REM2 (RRAD and GEM like GTPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 7.7), CNS E14 (RPKM 6.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.8 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54713676..54717889)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54476100..54480434)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits.
Title: Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits.
report that substitution of two key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ability to inhibit CaMKII
Title: The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity.
Our results highlight Rem2 as a unique molecule that transduces changes in neuronal activity detected at the cell membrane to morphologically relevant changes in gene expression in the nucleus
Title: Rem2 signaling affects neuronal structure and function in part by regulation of gene expression.
Study have shown that Rem2 is expressed in a variety of nervous system tissues, but is enriched in the basal ganglia. The function of Rem2 in the basal ganglia is unknown, but may be important for neuronal maturation during development, and/or neuroplasticity in adulthood.
Title: Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia.
Voltage dependant calcium channels blockade by Rem2 is likely to be controlled by both the localized concentration of membrane phosphorylated phosphatidylinositide lipids and direct 14-3-3 binding to the Rem2 C-terminus.
Title: Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.
Nuclear localization of RGK proteins (Rad, Rem, and Rem2) contributes to the suppression of RGK-mediated cell shape remodeling.
Title: Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTP-binding protein REM 2

Names: rad and Gem-like GTP-binding protein 2

NP_001411710.1

EC 3.6.5.2

NP_542764.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424781.1 → NP_001411710.1 GTP-binding protein REM 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC164433
NM_080726.4 → NP_542764.2 GTP-binding protein REM 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC164433

Consensus CDS

CCDS27090.2

UniProtKB/Swiss-Prot

Q8BPB1, Q8VEL9

UniProtKB/TrEMBL

E9Q4D5

Related

ENSMUSP00000127199.2, ENSMUST00000164766.8

Conserved Domains (2) summary

cd04148
Location:116 → 341

RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

smart00173
Location:116 → 279

RAS; Ras subfamily of RAS small GTPases