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    Col26a1 collagen, type XXVI, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 140709, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Col26a1provided by MGI
    Official Full Name
    collagen, type XXVI, alpha 1provided by MGI
    Primary source
    MGI:MGI:2155345
    See related
    Ensembl:ENSMUSG00000004415 AllianceGenome:MGI:2155345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emu2; Emid2; Col26a; 9430032K24Rik
    Summary
    Acts upstream of or within positive regulation of cell-substrate adhesion. Located in Golgi apparatus; endoplasmic reticulum; and extracellular matrix. Is expressed in several structures, including body cavity or lining; cerebellum; genitourinary system; respiratory system; and vertebral axis musculature. Orthologous to human COL26A1 (collagen type XXVI alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 44.2), CNS E11.5 (RPKM 18.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 76.03 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136770613..136912230, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136741759..136883376, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38722 Neighboring gene myosin, light chain 10, regulatory Neighboring gene STARR-seq mESC enhancer starr_14627 Neighboring gene predicted gene, 30654 Neighboring gene VISTA enhancer mm1626 Neighboring gene predicted gene 20485 Neighboring gene predicted gene 43649 Neighboring gene intraflagellar transport 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of two forms of the Ly-6.2 antigen showing differential expression. Sutton VR, et al. Immunogenetics, 1985. PMID 3874158
    2. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. Sato K, et al. J Biol Chem, 2002 Oct 4. PMID 12145293
    3. Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family. Braghetta P, et al. Matrix Biol, 2004 Jan. PMID 14996434
    4. Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement. Singh PNP, et al. Development, 2018 Mar 12. PMID 29467244
    5. Investigation of differentially expressed genes during the development of mouse cerebellum. Kagami Y, et al. Brain Res Gene Expr Patterns, 2001 Aug. PMID 15018818

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7475

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    collagen alpha-1(XXVI) chain
    Names
    Collagen XXVI
    EMI domain containing 2
    EMI domain-containing protein 2
    alpha-1 type XXVI collagen
    emilin and multimerin domain-containing protein 2
    procollagen, type XXVI, alpha 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346699.1 → NP_001333628.1  collagen alpha-1(XXVI) chain isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC140232, AC147987, AK076445, AK143515
      Consensus CDS
      CCDS84976.1
      UniProtKB/Swiss-Prot
      Q91VF6
      Related
      ENSMUSP00000106732.2, ENSMUST00000111103.2

    2. NM_024474.3 → NP_077794.2  collagen alpha-1(XXVI) chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_077794.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC140232, AC147987
      Consensus CDS
      CCDS19755.1
      UniProtKB/Swiss-Prot
      Q8K4P3, Q91VF6
      Related
      ENSMUSP00000052095.7, ENSMUST00000057497.13
      Conserved Domains (1) summary
      pfam07546
      Location:54 → 122
      EMI; EMI domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      136770613..136912230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504362.1 → XP_006504425.1  collagen alpha-1(XXVI) chain isoform X1

      Conserved Domains (1) summary
      pfam07546
      Location:48 → 81
      EMI; EMI domain

    2. XM_036164781.1 → XP_036020674.1  collagen alpha-1(XXVI) chain isoform X4

    3. XM_006504363.5 → XP_006504426.1  collagen alpha-1(XXVI) chain isoform X4

      See identical proteins and their annotated locations for XP_006504426.1

    4. XM_011240858.3 → XP_011239160.1  collagen alpha-1(XXVI) chain isoform X4

      See identical proteins and their annotated locations for XP_011239160.1

    5. XM_006504364.4 → XP_006504427.1  collagen alpha-1(XXVI) chain isoform X4

      See identical proteins and their annotated locations for XP_006504427.1

    6. XM_006504365.4 → XP_006504428.2  collagen alpha-1(XXVI) chain isoform X2

    7. XM_011240857.4 → XP_011239159.1  collagen alpha-1(XXVI) chain isoform X4

      See identical proteins and their annotated locations for XP_011239159.1

    8. XM_011240856.1 → XP_011239158.1  collagen alpha-1(XXVI) chain isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VF6.1 GenPept UniProtKB/Swiss-Prot:Q91VF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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