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    F10 coagulation factor X [ Mus musculus (house mouse) ]

    Gene ID: 14058, updated on 5-Mar-2024

    Summary

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    Official Symbol
    F10provided by MGI
    Official Full Name
    coagulation factor Xprovided by MGI
    Primary source
    MGI:MGI:103107
    See related
    Ensembl:ENSMUSG00000031444 AllianceGenome:MGI:103107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fX; Cf10
    Summary
    This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in liver E18 (RPKM 103.5), liver adult (RPKM 83.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13087308..13106676)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13037308..13056676)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CD24a antigen pseudogene Neighboring gene coagulation factor VII Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene PCI domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1752 Neighboring gene cullin 4A Neighboring gene microRNA 7065

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of coagulation factor Xa improves myocardial function during CVB3-induced myocarditis. Malz R, et al. Cardiovasc Ther, 2014 Jun. PMID 24533719
    2. Coagulation factor X interaction with macrophages through its N-glycans protects it from a rapid clearance. Kurdi M, et al. PLoS One, 2012. PMID 23049768, Free PMC Article
    3. Roles of coagulation pathway and factor Xa in the progression of diabetic nephropathy in db/db mice. Sumi A, et al. Biol Pharm Bull, 2011. PMID 21628879
    4. FXa-induced intracellular signaling links coagulation to neoangiogenesis: potential implications for fibrosis. Borensztajn K, et al. Biochim Biophys Acta, 2009 May. PMID 19339215
    5. A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. Tai SJ, et al. J Thromb Haemost, 2008 Feb. PMID 18036190, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers.
      Title: Intrinsic Expression of Coagulation Factors and Protease Activated Receptor 1 (PAR1) in Photoreceptors and Inner Retinal Layers.
    2. PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
      Title: Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
    3. annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa.
      Title: Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity.
    4. Enhanced FXa and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
      Title: Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy.
    5. Macrophages regulate FX plasma levels in an SR-AI-dependent manner.
      Title: Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X.
    6. Factor Xa has a role in inhibiting HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice
      Title: Factor Xa inhibits HMGB1-induced septic responses in human umbilical vein endothelial cells and in mice.
    7. Selective inhibition of FXa improves the left ventricular function during CVB3-induced myocarditis and seems to be associated with an improved myocardial remodeling.
      Title: Inhibition of coagulation factor Xa improves myocardial function during CVB3-induced myocarditis.
    8. Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.
      Title: Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.
    9. Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate.
      Title: Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate.
    10. There was no detectable increase in plasma levels of mouse FX after active-site inhibited human APC administration to mice overexpressing human EPCR. FX does not effectively interact with EPCR in vivo, at least in regards to the mouse system.
      Title: Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor X
    Names
    stuart factor
    NP_001229297.1
    NP_031998.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242368.1 → NP_001229297.1  coagulation factor X isoform 1 precursor

      See identical proteins and their annotated locations for NP_001229297.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC127308, BC050219
      Consensus CDS
      CCDS57606.1
      UniProtKB/TrEMBL
      Q3TDB9, Q3U3V1
      Related
      ENSMUSP00000033821.5, ENSMUST00000033821.11
      Conserved Domains (5) summary
      smart00020
      Location:243 → 471
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:36 → 97
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:98 → 134
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:244 → 473
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:141 → 176
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. NM_007972.4 → NP_031998.3  coagulation factor X isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_031998.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC127308, AF087644
      Consensus CDS
      CCDS40226.1
      UniProtKB/Swiss-Prot
      O54740, O88947, Q99L32
      UniProtKB/TrEMBL
      Q3TBR2, Q4FJS7
      Related
      ENSMUSP00000068389.6, ENSMUST00000063820.12
      Conserved Domains (5) summary
      smart00020
      Location:231 → 459
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:24 → 85
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:86 → 122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:232 → 461
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:129 → 164
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13087308..13106676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88947.1 GenPept UniProtKB/Swiss-Prot:O88947

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