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    Eri3 exoribonuclease 3 [ Mus musculus (house mouse) ]

    Gene ID: 140546, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Eri3provided by MGI
    Official Full Name
    exoribonuclease 3provided by MGI
    Primary source
    MGI:MGI:2153887
    See related
    Ensembl:ENSMUSG00000033423 AllianceGenome:MGI:2153887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PINT1; Prnpip1
    Summary
    Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; major salivary gland; and trigeminal nerve. Orthologous to human ERI3 (ERI1 exoribonuclease family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 32.0), ovary adult (RPKM 28.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eri3 in Genome Data Viewer
    Location:
    4 D1; 4 53.46 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117407416..117531494)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117550241..117674297)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 220 Neighboring gene predicted gene 12827 Neighboring gene predicted gene, 34669 Neighboring gene STARR-positive B cell enhancer mm9_chr4:117222596-117222897 Neighboring gene STARR-seq mESC enhancer starr_11185 Neighboring gene STARR-seq mESC enhancer starr_11187 Neighboring gene zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:117354782-117355011 Neighboring gene DNA methyltransferase 1-associated protein 1 Neighboring gene predicted gene, 34746

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels. Bian Y, et al. PLoS One, 2011. PMID 22039495, Free PMC Article
    2. PrPC directly interacts with proteins involved in signaling pathways. Spielhaupter C, et al. J Biol Chem, 2001 Nov 30. PMID 11571277
    3. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ERI1 exoribonuclease 3
    Names
    prion interactor 1
    prion protein interacting protein 1
    prion protein-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285899.2 → NP_001272828.1  ERI1 exoribonuclease 3 isoform b

      See identical proteins and their annotated locations for NP_001272828.1

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:105 → 282
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    2. NM_001285901.2 → NP_001272830.1  ERI1 exoribonuclease 3 isoform c

      See identical proteins and their annotated locations for NP_001272830.1

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    3. NM_001285902.2 → NP_001272831.1  ERI1 exoribonuclease 3 isoform d

      See identical proteins and their annotated locations for NP_001272831.1

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/Swiss-Prot
      Q8C460
      Conserved Domains (1) summary
      cd06133
      Location:1 → 146
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    4. NM_001356404.2 → NP_001343333.1  ERI1 exoribonuclease 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    5. NM_001356405.1 → NP_001343334.1  ERI1 exoribonuclease 3 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (e) has the same N- and C-termini, but is 2 aa shorter than isoform a.
      Source sequence(s)
      AK083017, BE944838, BY255598
      Conserved Domains (1) summary
      cd06133
      Location:144 → 321
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    6. NM_001379279.1 → NP_001366208.1  ERI1 exoribonuclease 3 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:146 → 345
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    7. NM_001379280.1 → NP_001366209.1  ERI1 exoribonuclease 3 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:107 → 284
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    8. NM_001379281.1 → NP_001366210.1  ERI1 exoribonuclease 3 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 267
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    9. NM_001379282.1 → NP_001366211.1  ERI1 exoribonuclease 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    10. NM_001379283.1 → NP_001366212.1  ERI1 exoribonuclease 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    11. NM_001379284.1 → NP_001366213.1  ERI1 exoribonuclease 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:1 → 146
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    12. NM_001379285.1 → NP_001366214.1  ERI1 exoribonuclease 3 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Conserved Domains (1) summary
      cd06133
      Location:35 → 205
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    13. NM_080469.5 → NP_536717.2  ERI1 exoribonuclease 3 isoform a

      See identical proteins and their annotated locations for NP_536717.2

      Status: VALIDATED

      Source sequence(s)
      AL645740, AL671520
      Consensus CDS
      CCDS18535.1
      UniProtKB/Swiss-Prot
      A2ADW0, A2ADW2, Q149R0, Q68FL7, Q8C460, Q923K5
      Related
      ENSMUSP00000042796.9, ENSMUST00000037127.15
      Conserved Domains (1) summary
      cd06133
      Location:146 → 323
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      117407416..117531494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319962.3 → XP_017175451.2  ERI1 exoribonuclease 3 isoform X5

      Conserved Domains (1) summary
      cd06133
      Location:121 → 285
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    2. XM_030253198.2 → XP_030109058.2  ERI1 exoribonuclease 3 isoform X8

      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:121 → 298
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    3. XM_036163665.1 → XP_036019558.1  ERI1 exoribonuclease 3 isoform X10

      Conserved Domains (1) summary
      cd06133
      Location:121 → 256
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    4. XM_030253202.1 → XP_030109062.1  ERI1 exoribonuclease 3 isoform X12

      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 245
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    5. XM_017319971.2 → XP_017175460.1  ERI1 exoribonuclease 3 isoform X13

      Conserved Domains (1) summary
      cd06133
      Location:1 → 133
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    6. XM_036163669.1 → XP_036019562.1  ERI1 exoribonuclease 3 isoform X14

      Conserved Domains (1) summary
      cd06133
      Location:1 → 168
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    7. XM_017319970.3 → XP_017175459.1  ERI1 exoribonuclease 3 isoform X13

      Conserved Domains (1) summary
      cd06133
      Location:1 → 133
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    8. XM_017319961.3 → XP_017175450.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68 → 232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    9. XM_030253200.1 → XP_030109060.1  ERI1 exoribonuclease 3 isoform X9

      Conserved Domains (1) summary
      cd06133
      Location:68 → 203
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    10. XM_017319964.3 → XP_017175453.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68 → 232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    11. XM_036163663.1 → XP_036019556.1  ERI1 exoribonuclease 3 isoform X6

      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 267
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    12. XM_017319972.3 → XP_017175461.1  ERI1 exoribonuclease 3 isoform X16

      Conserved Domains (1) summary
      cd06133
      Location:1 → 114
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    13. XM_017319965.3 → XP_017175454.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68 → 232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    14. XM_036163670.1 → XP_036019563.1  ERI1 exoribonuclease 3 isoform X15

      Conserved Domains (1) summary
      cd06133
      Location:1 → 146
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    15. XM_011240437.4 → XP_011238739.2  ERI1 exoribonuclease 3 isoform X1

      Conserved Domains (1) summary
      cd06133
      Location:146 → 310
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    16. XM_030253195.2 → XP_030109055.1  ERI1 exoribonuclease 3 isoform X3

      Conserved Domains (1) summary
      cd06133
      Location:146 → 281
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    17. XM_017319960.3 → XP_017175449.1  ERI1 exoribonuclease 3 isoform X2

      Conserved Domains (1) summary
      cd06133
      Location:144 → 308
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    18. XM_036163661.1 → XP_036019554.1  ERI1 exoribonuclease 3 isoform X6

      UniProtKB/TrEMBL
      Q8VC93
      Conserved Domains (1) summary
      cd06133
      Location:68 → 267
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    19. XM_036163664.1 → XP_036019557.1  ERI1 exoribonuclease 3 isoform X9

      Conserved Domains (1) summary
      cd06133
      Location:68 → 203
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    20. XM_036163671.1 → XP_036019564.1  ERI1 exoribonuclease 3 isoform X16

      Related
      ENSMUST00000146384.8
      Conserved Domains (1) summary
      cd06133
      Location:1 → 114
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    21. XM_036163667.1 → XP_036019560.1  ERI1 exoribonuclease 3 isoform X13

      Conserved Domains (1) summary
      cd06133
      Location:1 → 133
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    22. XM_036163668.1 → XP_036019561.1  ERI1 exoribonuclease 3 isoform X14

      Conserved Domains (1) summary
      cd06133
      Location:1 → 168
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    23. XM_030253209.1 → XP_030109069.1  ERI1 exoribonuclease 3 isoform X16

      Conserved Domains (1) summary
      cd06133
      Location:1 → 114
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    24. XM_036163666.1 → XP_036019559.1  ERI1 exoribonuclease 3 isoform X11

      Conserved Domains (1) summary
      cd06133
      Location:35 → 192
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    25. XM_017319966.3 → XP_017175455.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68 → 232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    26. XM_030253208.1 → XP_030109068.1  ERI1 exoribonuclease 3 isoform X9

      Conserved Domains (1) summary
      cd06133
      Location:68 → 203
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    27. XM_036163662.1 → XP_036019555.1  ERI1 exoribonuclease 3 isoform X7

      Conserved Domains (1) summary
      cd06133
      Location:105 → 269
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    28. XM_017319967.2 → XP_017175456.1  ERI1 exoribonuclease 3 isoform X4

      Conserved Domains (1) summary
      cd06133
      Location:68 → 232
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins

    RNA

    1. XR_003954874.2 RNA Sequence

    2. XR_004941810.1 RNA Sequence

    3. XR_003954875.2 RNA Sequence

    4. XR_003954876.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C460.1 GenPept UniProtKB/Swiss-Prot:Q8C460

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