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    Eya2 EYA transcriptional coactivator and phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 14049, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Eya2provided by MGI
    Official Full Name
    EYA transcriptional coactivator and phosphatase 2provided by MGI
    Primary source
    MGI:MGI:109341
    See related
    Ensembl:ENSMUSG00000017897 AllianceGenome:MGI:109341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eab1
    Summary
    This gene encodes a member of the eyes absent protein family. The encoded protein is a tyrosine phosphatase which acts as a transcriptional activator during development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Broad expression in ovary adult (RPKM 28.8), lung adult (RPKM 23.2) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 85.83 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165436892..165613645)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165595028..165771727)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transformation related protein 53 regulating kinase A Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 10 Neighboring gene predicted gene, 29993 Neighboring gene STARR-seq mESC enhancer starr_06353 Neighboring gene STARR-positive B cell enhancer ABC_E4519 Neighboring gene STARR-seq mESC enhancer starr_06355 Neighboring gene zinc finger, MYND-type containing 8 Neighboring gene STARR-seq mESC enhancer starr_06364 Neighboring gene RIKEN cDNA 1810021M19 gene Neighboring gene STARR-positive B cell enhancer ABC_E4520 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165711164-165711317 Neighboring gene STARR-positive B cell enhancer ABC_E647 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:165715911-165716111 Neighboring gene predicted gene 11465

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Eya2 expression during mouse embryonic development revealed by Eya2(lacZ) knockin reporter and homozygous mice show mild hearing loss. Zhang T, et al. Dev Dyn, 2021 Oct. PMID 33715274, Free PMC Article
    2. Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells. Maharjan BD, et al. Int J Oncol, 2019 Mar. PMID 30628662
    3. The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling. Lee SH, et al. J Mol Cell Cardiol, 2009 Apr. PMID 19272299
    4. Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. Lee SH, et al. J Mol Cell Cardiol, 2012 Mar. PMID 22197309
    5. Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Xu PX, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342347, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eya2 expression during mouse embryonic development revealed by Eya2(lacZ) knockin reporter and homozygous mice show mild hearing loss.
      Title: Eya2 expression during mouse embryonic development revealed by Eya2(lacZ) knockin reporter and homozygous mice show mild hearing loss.
    2. Immunoglobulin enhancerbinding factor/hepatic leukemia factor oncogenic fusion protein (E2AHLF) enhances the EYA transcriptional coactivator and phosphatase 2 (Eya2) expression by binding to the promoter region containing the E2AHLFbinding consensus sequence. Eya2 knockdown in E2AHLFimmortalized cells resulted in reduced colonyforming efficiency.
      Title: Eya2 is critical for the E2A‑HLF‑mediated immortalization of mouse hematopoietic stem/progenitor cells.
    3. Eya2 in a physical complex with Six1 plays a critical role in physiological hypertrophy.
      Title: Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy.
    4. Eya2 prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/Akt/mTOR signaling pathway.
      Title: The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling.
    5. Eya2 protein is required for hypaxial somitic myogenesis in the mouse embryo
      Title: Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial outer membrane permeabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within striated muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eyes absent homolog 2
    Names
    eyes absent 2 homolog
    NP_001258891.1
    NP_001258892.1
    NP_034295.1
    XP_006498802.1
    XP_036014160.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271962.2 → NP_001258891.1  eyes absent homolog 2

      See identical proteins and their annotated locations for NP_001258891.1

      Status: VALIDATED

      Source sequence(s)
      AL591712, AL591805
      Consensus CDS
      CCDS17084.1
      UniProtKB/Swiss-Prot
      A2A5S4, O08575, P97925
      UniProtKB/TrEMBL
      Q3UV00
      Conserved Domains (2) summary
      PTZ00395
      Location:54 → 262
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:261 → 532
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    2. NM_001271963.2 → NP_001258892.1  eyes absent homolog 2

      See identical proteins and their annotated locations for NP_001258892.1

      Status: VALIDATED

      Source sequence(s)
      AL591712, AL591805
      Consensus CDS
      CCDS17084.1
      UniProtKB/Swiss-Prot
      A2A5S4, O08575, P97925
      UniProtKB/TrEMBL
      Q3UV00
      Related
      ENSMUSP00000085455.7, ENSMUST00000088132.13
      Conserved Domains (2) summary
      PTZ00395
      Location:54 → 262
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:261 → 532
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    3. NM_010165.4 → NP_034295.1  eyes absent homolog 2

      See identical proteins and their annotated locations for NP_034295.1

      Status: VALIDATED

      Source sequence(s)
      AL591712
      Consensus CDS
      CCDS17084.1
      UniProtKB/Swiss-Prot
      A2A5S4, O08575, P97925
      UniProtKB/TrEMBL
      Q3UV00
      Related
      ENSMUSP00000066244.8, ENSMUST00000063433.8
      Conserved Domains (2) summary
      PTZ00395
      Location:54 → 262
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:261 → 532
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165436892..165613645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158267.1 → XP_036014160.1  eyes absent homolog 2 isoform X1

      UniProtKB/TrEMBL
      Q3UV00, Q811N7
      Conserved Domains (2) summary
      PTZ00395
      Location:54 → 262
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:261 → 502
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    2. XM_006498739.4 → XP_006498802.1  eyes absent homolog 2 isoform X2

      UniProtKB/TrEMBL
      Q3UV00
      Conserved Domains (2) summary
      PTZ00395
      Location:2 → 203
      PTZ00395; Sec24-related protein; Provisional
      cd02601
      Location:202 → 473
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08575.1 GenPept UniProtKB/Swiss-Prot:O08575

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