U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 [ Mus musculus (house mouse) ]

    Gene ID: 13872, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ercc3provided by MGI
    Official Full Name
    excision repair cross-complementing rodent repair deficiency, complementation group 3provided by MGI
    Primary source
    MGI:MGI:95414
    See related
    Ensembl:ENSMUSG00000024382 AllianceGenome:MGI:95414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XPB; Ercc-3; BTF2 p89
    Summary
    Enables ATP hydrolysis activity and promoter-specific chromatin binding activity. Acts upstream of or within UV protection and transcription elongation from RNA polymerase I promoter. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex; nucleotide-excision repair factor 3 complex; and transcription preinitiation complex. Is expressed in several structures, including brain; eye; liver; oral region epithelium; and tooth. Used to study xeroderma pigmentosum group B. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 17.5), bladder adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    18 B1; 18 17.97 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32373357..32403206)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32240304..32270151)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11799 Neighboring gene predicted gene, 26717 Neighboring gene predicted gene, 34806 Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene STARR-seq mESC enhancer starr_44156 Neighboring gene STARR-positive B cell enhancer ABC_E5649 Neighboring gene STARR-seq mESC enhancer starr_44157 Neighboring gene RIKEN cDNA A830052D11 gene Neighboring gene bridging integrator 1 Neighboring gene testis expressed 51

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differentiation driven changes in the dynamic organization of Basal transcription initiation. Giglia-Mari G, et al. PLoS Biol, 2009 Oct. PMID 19841728, Free PMC Article
    2. Expression of the excision repair gene, ERCC3 (excision repair cross-complementing), during mouse development. Hubank M, et al. Brain Res Dev Brain Res, 1994 Aug 12. PMID 7805288
    3. Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome. Weeda G, et al. Carcinogenesis, 1991 Dec. PMID 1747940
    4. ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair. Mourgues S, et al. Proc Natl Acad Sci U S A, 2013 Oct 29. PMID 24127601, Free PMC Article
    5. Generation of DNA single-strand displacement by compromised nucleotide excision repair. Godon C, et al. EMBO J, 2012 Aug 29. PMID 22863773, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA topological change ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within UV protection IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hair cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hair cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair, DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transcription elongation by RNA polymerase I EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleotide-excision repair factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    general transcription and DNA repair factor IIH helicase subunit XPB
    Names
    DNA excision repair protein ERCC-3
    DNA repair protein complementing XP-B cells
    TFIIH 89 kDa subunit
    TFIIH basal transcription factor complex helicase XPB subunit
    basic transcription factor 2 89 kDa subunit
    xeroderma pigmentosum group B-complementing protein
    NP_598419.1
    XP_006525699.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133658.2 → NP_598419.1  general transcription and DNA repair factor IIH helicase subunit XPB

      See identical proteins and their annotated locations for NP_598419.1

      Status: VALIDATED

      Source sequence(s)
      BC022956, BY273530, S71186
      Consensus CDS
      CCDS29118.1
      UniProtKB/Swiss-Prot
      P49135
      UniProtKB/TrEMBL
      Q3U3I5
      Related
      ENSMUSP00000025241.7, ENSMUST00000025241.7
      Conserved Domains (4) summary
      TIGR00603
      Location:60 → 780
      rad25; DNA repair helicase rad25
      pfam04851
      Location:316 → 473
      ResIII; Type III restriction enzyme, res subunit
      pfam13625
      Location:76 → 198
      Helicase_C_3; Helicase conserved C-terminal domain
      pfam16203
      Location:497 → 740
      ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      32373357..32403206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525636.2 → XP_006525699.1  general transcription and DNA repair factor IIH helicase subunit XPB isoform X1

      Conserved Domains (1) summary
      TIGR00603
      Location:60 → 578
      rad25; DNA repair helicase rad25

    RNA

    1. XR_385973.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49135.1 GenPept UniProtKB/Swiss-Prot:P49135

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous