Stx2 syntaxin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stx2provided by MGI
Official Full Name: syntaxin 2provided by MGI
Primary source: MGI:MGI:108059
See related: Ensembl:ENSMUSG00000029428 AllianceGenome:MGI:108059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epim; Syn-2; repro34; G1-536-1
Summary: Enables calcium-dependent protein binding activity. Involved in acrosome reaction. Acts upstream of or within cell differentiation. Located in several cellular components, including cell surface; cell-cell junction; and membrane raft. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and respiratory system. Orthologous to human STX2 (syntaxin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 38.2), liver E14 (RPKM 32.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G1.3; 5 67.99 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (129061621..129085664, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (128984557..129008600, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased expression of epimorphin in a peritoneal fibrosis mouse model.
Title: Increased expression of epimorphin in a peritoneal fibrosis mouse model.
he patient showed azoospermia, relatively small testes, and a mildly elevated follicle stimulating hormone level, but no additional clinical features. Testicular histology of the patient showed universal maturation arrest and multinucleated spermatocytes, which have also been observed in mice lacking Stx2. PCR-based cDNA screening revealed wildtype STX2 expression in various tissues including the testis
Title: STX2 is a causative gene for nonobstructive azoospermia.
Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin secretion. The increase in insulin exocytosis was attributed mainly to an enhanced recruitment of the larger pool of newcomer secretory granules (SGs) that undergoes no residence time on plasma membrane before fusion and, to a lesser extent, also the predocked SGs.
Title: Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis.
The selectivity in syntaxin binding and apical protein redistribution further suggests that rab17 and syntaxin 2 mediate fusion of transcytotic vesicles at the apical surface.
Title: The GTP-bound and Sumoylated Form of the rab17 Small Molecular Weight GTPase Selectively Binds Syntaxin 2 in Polarized Hepatic WIF-B Cells.
It was concluded that Epim deletion inhibits polyposis in Apcmin/+ mice, associated with increased mucosal TGF-beta signaling and decreased myofibroblast HGF expression and secretion.
Title: Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion.
Overexpression of Epim expression is associated with mammary carcinoma.
Title: Epimorphin is a novel regulator of the progesterone receptor isoform-a.
These results suggest that STX2 plays roles in transport and/or subcellular distribution of sulfoglycolipids.
Title: t-SNARE Syntaxin2 (STX2) is implicated in intracellular transport of sulfoglycolipids during meiotic prophase in mouse spermatogenesis.
epimorphin modulates the signaling pathways mediated by EGFR for epidermal tissue organization
Title: Extracellular epimorphin modulates epidermal differentiation signals mediated by epidermal growth factor receptor.
Epimorphin regulates bile duct formation via effects on mitosis orientation
Title: Epimorphin regulates bile duct formation via effects on mitosis orientation in rat liver epithelial stem-like cells.
Epimorphin has a pivotal role in the repair of renal fibrosis by modulating both extracellular matrix (ECM) degradation and its production.
Title: Involvement of epimorphin in the repair of experimental renal fibrosis in mice.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stx2 (e-PCR), detects polymorphism
- UniSTS:506687

AW538950 (e-PCR)
- UniSTS:179279

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cornified envelope assembly	ISO Inferred from Sequence Orthology more info
involved_in digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	IC Inferred by Curator more info	PubMed
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in midbody abscission	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: syntaxin-2

Names: epimorphin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286033.1 → NP_001272962.1 syntaxin-2 isoform b

See identical proteins and their annotated locations for NP_001272962.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon, which results in an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AC110566, AK167577, BC046279, CJ232084

Consensus CDS

CCDS71672.1

UniProtKB/Swiss-Prot

Q00262

UniProtKB/TrEMBL

Q3TJ55

Related

ENSMUSP00000098247.4, ENSMUST00000100680.10

Conserved Domains (3) summary

cd00179
Location:30 → 181

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15882
Location:191 → 259

SNARE_syntaxin2; SNARE motif of syntaxin 2

pfam00804
Location:30 → 227

Syntaxin; Syntaxin
NM_001286034.1 → NP_001272963.1 syntaxin-2 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream in-frame start codon, and lacks an exon, which results in an alternate 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AC110566, AK167577, BC046279, CJ232084

UniProtKB/TrEMBL

Q3TN38

Conserved Domains (3) summary

cd00179
Location:1 → 152

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15882
Location:162 → 230

SNARE_syntaxin2; SNARE motif of syntaxin 2

pfam00804
Location:1 → 198

Syntaxin; Syntaxin
NM_001359022.1 → NP_001345951.1 syntaxin-2 isoform d precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC110566

Conserved Domains (1) summary

cl22856
Location:26 → 60

SNARE; SNARE motif
NM_007941.3 → NP_031967.2 syntaxin-2 isoform a

See identical proteins and their annotated locations for NP_031967.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC110566, AK146462, BC046279, CJ232084

Consensus CDS

CCDS19692.1

UniProtKB/Swiss-Prot

Q00262

UniProtKB/TrEMBL

Q80W45

Related

ENSMUSP00000031378.7, ENSMUST00000031378.14

Conserved Domains (3) summary

cd00179
Location:30 → 181

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...

cd15882
Location:191 → 259

SNARE_syntaxin2; SNARE motif of syntaxin 2

pfam00804
Location:30 → 227

Syntaxin; Syntaxin

RNA

NR_152615.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC110566