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    Ephb4 Eph receptor B4 [ Mus musculus (house mouse) ]

    Gene ID: 13846, updated on 12-May-2024

    Summary

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    Official Symbol
    Ephb4provided by MGI
    Official Full Name
    Eph receptor B4provided by MGI
    Primary source
    MGI:MGI:104757
    See related
    Ensembl:ENSMUSG00000029710 AllianceGenome:MGI:104757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htk; MDK2; Myk1; Tyro11; b2b2412Clo
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Involved in angiogenesis; ephrin receptor signaling pathway; and heart morphogenesis. Acts upstream of or within positive regulation of T cell costimulation; positive regulation of aorta morphogenesis; and venous blood vessel morphogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human EPHB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 50.3), limb E14.5 (RPKM 38.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G2; 5 76.38 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137348371..137372784)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137350109..137374522)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 (potassium/chloride transporters), member 9 Neighboring gene STARR-positive B cell enhancer ABC_E9655 Neighboring gene STARR-seq mESC enhancer starr_14641 Neighboring gene predicted gene, 52791 Neighboring gene STARR-seq mESC enhancer starr_14643 Neighboring gene zonadhesin Neighboring gene ribosomal protein L36, pseudogene 9 Neighboring gene predicted gene, 38725

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Insulin induces insulin receptor degradation in the liver through EphB4. Liu X, et al. Nat Metab, 2022 Sep. PMID 36131205
    2. Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke. Wang J, et al. Mol Med Rep, 2021 Nov. PMID 34476505, Free PMC Article
    3. EphB4 inhibitor overcome the acquired resistance to cisplatin in melanomas xenograft model. Yang X, et al. J Pharmacol Sci, 2015 Sep. PMID 26390965
    4. EPHB4 Protein Expression in Vascular Smooth Muscle Cells Regulates Their Contractility, and EPHB4 Deletion Leads to Hypotension in Mice. Wang Y, et al. J Biol Chem, 2015 May 29. PMID 25903126, Free PMC Article
    5. The in vivo effect of prophylactic subchondral bone protection of osteoarthritic synovial membrane in bone-specific Ephb4-overexpressing mice. Valverde-Franco G, et al. Am J Pathol, 2015 Feb. PMID 25453723

    See all (197) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortiondagger.
      Title: EGR1 modulates EPHB4-induced trophoblast dysfunction in recurrent spontaneous abortion†.
    2. Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
      Title: Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension.
    3. Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
      Title: Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake.
    4. Insulin induces insulin receptor degradation in the liver through EphB4.
      Title: Insulin induces insulin receptor degradation in the liver through EphB4.
    5. EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
      Title: EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.
    6. Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
      Title: Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells.
    7. Mutations in EPHB4 cause human venous valve aplasia.
      Title: Mutations in EPHB4 cause human venous valve aplasia.
    8. Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
      Title: Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke.
    9. Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
      Title: Expression and localisation of ephrin-B1 and EphB4 in steroidogenic cells in the naturally cycling mouse ovary.
    10. Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
      Title: Ligand-Dependent and Ligand-Independent Effects of Ephrin-B2-EphB4 Signaling in Melanoma Metastatic Spine Disease.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell costimulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within venous blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-B receptor 4
    Names
    developmental kinase 2
    hepatoma transmembrane kinase
    mDK-2
    tyrosine kinase MYK-1
    NP_001153043.1
    NP_034274.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159571.1 → NP_001153043.1  ephrin type-B receptor 4 isoform a precursor

      See identical proteins and their annotated locations for NP_001153043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK046884, AK049340, BB677774
      Consensus CDS
      CCDS51671.1
      UniProtKB/TrEMBL
      Q3V1K8, Q8C7S3, Q8C8K1
      Related
      ENSMUSP00000106684.3, ENSMUST00000111055.9
      Conserved Domains (7) summary
      cd05065
      Location:619 → 887
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09554
      Location:916 → 982
      SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
      smart00454
      Location:913 → 980
      SAM; Sterile alpha motif
      cd10474
      Location:17 → 196
      EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
      cd00063
      Location:443 → 535
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:624 → 883
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:571 → 619
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    2. NM_010144.6 → NP_034274.4  ephrin type-B receptor 4 isoform b precursor

      See identical proteins and their annotated locations for NP_034274.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AK049340, AK132392, BB677774, BC090839
      Consensus CDS
      CCDS19767.1
      UniProtKB/Swiss-Prot
      P54761, Q60627, Q99MR2
      UniProtKB/TrEMBL
      Q3V1K8, Q8C7S3
      Related
      ENSMUSP00000051622.9, ENSMUST00000061244.15
      Conserved Domains (7) summary
      cd05065
      Location:610 → 878
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09554
      Location:907 → 973
      SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
      smart00454
      Location:904 → 971
      SAM; Sterile alpha motif
      cd10474
      Location:17 → 196
      EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
      cd00063
      Location:434 → 526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:615 → 874
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:562 → 610
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137348371..137372784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54761.2 GenPept UniProtKB/Swiss-Prot:P54761

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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