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    Epha6 Eph receptor A6 [ Mus musculus (house mouse) ]

    Gene ID: 13840, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Epha6provided by MGI
    Official Full Name
    Eph receptor A6provided by MGI
    Primary source
    MGI:MGI:108034
    See related
    Ensembl:ENSMUSG00000055540 AllianceGenome:MGI:108034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ehk2; EHK-2; Hek12; m-ehk2
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; endometrium; male reproductive gland or organ; and sensory organ. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 1.8), cortex adult (RPKM 1.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C1.3; 16 34.83 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (59473424..60431196, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (59641433..60610911, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41109 Neighboring gene STARR-seq mESC enhancer starr_41110 Neighboring gene RIKEN cDNA 4930547E14 gene Neighboring gene STARR-positive B cell enhancer ABC_E11790 Neighboring gene beta-gamma crystallin domain containing 3 Neighboring gene ribosomal oxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_41112 Neighboring gene ADP-ribosylation factor-like 6 Neighboring gene STARR-seq mESC enhancer starr_41113 Neighboring gene STARR-seq mESC enhancer starr_41115 Neighboring gene predicted gene 4660 Neighboring gene STARR-seq mESC enhancer starr_41116 Neighboring gene predicted gene 9017 Neighboring gene predicted gene, 23852 Neighboring gene STARR-seq mESC enhancer starr_41118 Neighboring gene STARR-seq mESC enhancer starr_41119 Neighboring gene protein FAM60A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Learning and memory impairment in Eph receptor A6 knockout mice. Savelieva KV, et al. Neurosci Lett, 2008 Jun 20. PMID 18450376
    2. Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea. Lee AM, et al. DNA Cell Biol, 1996 Oct. PMID 8892754
    3. Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells. Wang J, et al. J Biol Chem, 2016 Aug 26. PMID 27402841, Free PMC Article
    4. A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas. Marcelli F, et al. PLoS One, 2014. PMID 24945320, Free PMC Article
    5. Transcription factor Foxd1 is required for the specification of the temporal retina in mammals. Carreres MI, et al. J Neurosci, 2011 Apr 13. PMID 21490208, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPHA6, a gene implicated in retinal axon guidance, is one of HMX1 targets in eye development.
      Title: A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas.
    2. These findings suggest that EphA6, in line with a number of other Eph receptors and their ephrin ligands, is involved in neural circuits underlying aspects of learning and memory.
      Title: Learning and memory impairment in Eph receptor A6 knockout mice.
    3. HOXA13 directly regulates EphA6 and EphA7 in the developing genital tubercle.
      Title: HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 6
    Names
    EPH homology kinase 2
    NP_031964.2
    XP_006521850.1
    XP_011244128.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007938.2 → NP_031964.2  ephrin type-A receptor 6

      See identical proteins and their annotated locations for NP_031964.2

      Status: VALIDATED

      Source sequence(s)
      AC118603, AC122318, AC131707, AC133940, AC134526, AC154212, AC154473, AC154632, CT009682
      Consensus CDS
      CCDS28260.2
      UniProtKB/Swiss-Prot
      B9EIV2, Q62413, Q8CCN2
      UniProtKB/TrEMBL
      G1K381
      Related
      ENSMUSP00000066734.7, ENSMUST00000068860.13
      Conserved Domains (9) summary
      cd09547
      Location:1055 → 1118
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      smart00454
      Location:1052 → 1119
      SAM; Sterile alpha motif
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
      cd00063
      Location:549 → 628
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:720 → 1028
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:427 → 521
      fn3; Fibronectin type III domain
      pfam07699
      Location:370 → 406
      GCC2_GCC3; GCC2 and GCC3
      pfam07714
      Location:725 → 1024
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:648 → 720
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      59473424..60431196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521787.4 → XP_006521850.1  ephrin type-A receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      B9EIV2, Q62413, Q8CCN2
      Conserved Domains (7) summary
      cd09547
      Location:899 → 962
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      cd00063
      Location:393 → 472
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:564 → 872
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07699
      Location:214 → 250
      Ephrin_rec_like; Putative ephrin-receptor like
      pfam00041
      Location:271 → 361
      fn3; Fibronectin type III domain
      pfam14575
      Location:492 → 564
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1 → 144
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    2. XM_011245826.4 → XP_011244128.1  ephrin type-A receptor 6 isoform X2

      Conserved Domains (1) summary
      cd10484
      Location:128 → 300
      EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62413.2 GenPept UniProtKB/Swiss-Prot:Q62413

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