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    Elk3 ELK3, member of ETS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 13713, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Elk3provided by MGI
    Official Full Name
    ELK3, member of ETS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:101762
    See related
    Ensembl:ENSMUSG00000008398 AllianceGenome:MGI:101762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Erp; Net; Etrp; Sap-2; D430049E23Rik
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within angiogenesis; regulation of transcription, DNA-templated; and wound healing. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study congenital chylothorax. Orthologous to human ELK3 (ETS transcription factor ELK3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 24.3), limb E14.5 (RPKM 16.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C2; 10 48.04 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93083277..93147021, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93247415..93311159, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40741 Neighboring gene STARR-positive B cell enhancer mm9_chr10:92631736-92632037 Neighboring gene microRNA 1931 Neighboring gene cyclin dependent kinase 17 Neighboring gene STARR-seq mESC enhancer starr_27570 Neighboring gene STARR-seq mESC enhancer starr_27572 Neighboring gene STARR-seq mESC enhancer starr_27573 Neighboring gene predicted gene, 32604 Neighboring gene STARR-positive B cell enhancer ABC_E5168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:92757691-92757800 Neighboring gene STARR-seq mESC enhancer starr_27576 Neighboring gene predicted gene, 32551 Neighboring gene STARR-positive B cell enhancer ABC_E8357 Neighboring gene STARR-seq mESC enhancer starr_27578 Neighboring gene predicted gene, 32688 Neighboring gene STARR-positive B cell enhancer ABC_E8358 Neighboring gene STARR-positive B cell enhancer ABC_E5169 Neighboring gene predicted gene, 17745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ternary complex factor net is downregulated by hypoxia and regulates hypoxia-responsive genes. Gross C, et al. Mol Cell Biol, 2007 Jun. PMID 17403894, Free PMC Article
    2. Net-b, a Ras-insensitive factor that forms ternary complexes with serum response factor on the serum response element of the fos promoter. Giovane A, et al. Mol Cell Biol, 1997 Oct. PMID 9315625, Free PMC Article
    3. Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity. Nozaki M, et al. DNA Cell Biol, 1996 Oct. PMID 8892757
    4. ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development. Lopez M, et al. Mol Cell Biol, 1994 May. PMID 7909357, Free PMC Article
    5. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease. Li TZ, et al. Commun Biol, 2023 Jul 3. PMID 37400491, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM2.5.
      Title: Hub gene ELK3-mediated reprogramming lipid metabolism regulates phenotypic switching of pulmonary artery smooth muscle cells to develop pulmonary arterial hypertension induced by PM(2.5).
    2. The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
      Title: The Elk-3 target Abhd10 ameliorates hepatotoxic injury and fibrosis in alcoholic liver disease.
    3. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
      Title: Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
    4. Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression.
      Title: Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression.
    5. Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling.
      Title: Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition.
    6. Elk3 has distinct roles in maintaining retinal artery integrity.
      Title: Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.
    7. coexpression of KLF4 led to repression of Elk-3 promoter activity
      Title: Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages.
    8. ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density.
      Title: Cell density-dependent nuclear accumulation of ELK3 is involved in suppression of PAI-1 expression.
    9. Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
      Title: Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
    10. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles
      Title: Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine-rich negative regulatory element binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ETS domain-containing protein Elk-3
    Names
    ETS-domain protein ELK-3
    ETS-related protein ERP
    ETS-related protein NET

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282967.1 → NP_001269896.1  ETS domain-containing protein Elk-3 isoform Elk3d

      See identical proteins and their annotated locations for NP_001269896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks exon 3, but maintains the reading frame compared to variant 1. The resulting isoform (Elk3d) lacks an internal protein segment compared to isoform Elk3. Unlike isoform Elk3, this isoform is predominantly localized in the cytosol and has been shown to activate transcription (PMID:20304071).
      Source sequence(s)
      AC140379, AC161054
      Consensus CDS
      CCDS70097.1
      UniProtKB/TrEMBL
      G3UVW8
      Related
      ENSMUSP00000121754.2, ENSMUST00000151153.2
      Conserved Domains (1) summary
      smart00413
      Location:5 → 69
      ETS; erythroblast transformation specific domain

    2. NM_001322265.1 → NP_001309194.1  ETS domain-containing protein Elk-3 isoform Elk3c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is alternatively spliced at exon 3, which causes a frameshift compared to variant 1. The resulting isoform (Elk3c, also known as Net-c) is shorter, with a distinct C-terminus compared to isoform Elk3.
      Source sequence(s)
      AC140379, AC161054, AK052546
      UniProtKB/TrEMBL
      C7C6B3
      Conserved Domains (1) summary
      smart00413
      Location:5 → 89
      ETS; erythroblast transformation specific domain

    3. NM_001322268.1 → NP_001309197.1  ETS domain-containing protein Elk-3 isoform Elk3b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is alternatively spliced and lacks the mid-region of exon 3, which causes a frameshift compared to variant 1. The resulting isoform (Elk3b, also known as Net-b) is shorter, with a distinct C-terminus compared to isoform Elk3. Note, variant 2 is borderline nonsense-mediated mRNA decay (NMD) candidate; however, this variant-specific protein expression has been observed in vivo (PMID:9315625).
      Source sequence(s)
      AC140379, AC161054, AK052546
      Consensus CDS
      CCDS83749.1
      UniProtKB/TrEMBL
      C7C6B2, G3UVX2
      Related
      ENSMUSP00000122324.2, ENSMUST00000129827.8
      Conserved Domains (1) summary
      smart00413
      Location:5 → 89
      ETS; erythroblast transformation specific domain

    4. NM_013508.2 → NP_038536.2  ETS domain-containing protein Elk-3 isoform Elk3

      See identical proteins and their annotated locations for NP_038536.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (Elk3, also known as Net). This isoform is predominantly localized in the nucleus and has been shown to inhibit transcription (PMID:20304071).
      Source sequence(s)
      AC140379, AC161054, AK052546
      Consensus CDS
      CCDS24124.1
      UniProtKB/Swiss-Prot
      P41971, P97747, Q62346, Q8BWH1
      UniProtKB/TrEMBL
      Q3UZH4
      Related
      ENSMUSP00000008542.6, ENSMUST00000008542.12
      Conserved Domains (1) summary
      smart00413
      Location:5 → 89
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93083277..93147021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244871.2 → XP_030100731.1  ETS domain-containing protein Elk-3 isoform X1

      UniProtKB/Swiss-Prot
      P41971, P97747, Q62346, Q8BWH1
      UniProtKB/TrEMBL
      Q3UZH4
      Conserved Domains (1) summary
      smart00413
      Location:5 → 89
      ETS; erythroblast transformation specific domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_205536.1: Suppressed sequence

      Description
      NM_205536.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41971.3 GenPept UniProtKB/Swiss-Prot:P41971

    Gene LinkOut

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