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    Eif3a eukaryotic translation initiation factor 3, subunit A [ Mus musculus (house mouse) ]

    Gene ID: 13669, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Eif3aprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Aprovided by MGI
    Primary source
    MGI:MGI:95301
    See related
    Ensembl:ENSMUSG00000024991 AllianceGenome:MGI:95301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csma; Eif3; Eif3s10; mKIAA0139; A830012B05Rik
    Summary
    Contributes to translation initiation factor activity. Involved in formation of cytoplasmic translation initiation complex. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in postsynaptic density. Is expressed in central nervous system; retina; and testis. Orthologous to human EIF3A (eukaryotic translation initiation factor 3 subunit A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 81.9), liver E14 (RPKM 47.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 D3; 19 56.52 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60749554..60779131, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60761116..60790693, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34459 Neighboring gene predicted gene, 34406 Neighboring gene STARR-seq mESC enhancer starr_46601 Neighboring gene STARR-positive B cell enhancer ABC_E11044 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene microRNA 3084-2 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene STARR-positive B cell enhancer ABC_E7677 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60887142-60887443 Neighboring gene 60S ribosomal protein L26-like Neighboring gene DENN domain containing 10 Neighboring gene sideroflexin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e). Mayeur GL, et al. FEBS Lett, 2002 Mar 6. PMID 11904180
    2. The centrosomal protein centrosomin A and the nuclear protein centrosomin B derive from one gene by post-transcriptional processes involving RNA editing. Petzelt C, et al. J Cell Sci, 1997 Oct. PMID 9372446
    3. Murine cDNAs coding for the centrosomal antigen centrosomin A. Joswig G, et al. J Cell Sci, 1991 Jan. PMID 1829085
    4. Role of eIF3a in regulating cell cycle progression. Dong Z, et al. Exp Cell Res, 2009 Jul 1. PMID 19327350
    5. Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development. Liu Z, et al. Differentiation, 2007 Sep. PMID 17381544

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [IL-33 up-regulates eIF3a expression by activating NF-kappaB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].
      Title: [IL-33 up-regulates eIF3a expression by activating NF-κB signaling pathway to mediate the proliferation and differentiation of mouse pulmonary myofibroblasts and aggravate pulmonary fibrosis].
    2. The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations.
      Title: The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
    3. May play some roles in development and differentiation; decreased eIF3a expression may be a pre-requisite of intestinal epithelial cell differentiation.
      Title: Role of eIF3a (eIF3 p170) in intestinal cell differentiation and its association with early development.
    4. eIF3a expression oscillated with cell cycle and peaked in S phase. Reducing eIF3a expression also reduced cell proliferation rate by elongating cell cycle but did not change the cell cycle distribution.
      Title: Role of eIF3a in regulating cell cycle progression.
    5. Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation
      Title: Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formation of cytoplasmic translation initiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational termination-reinitiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3e IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of multi-eIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit A
    Names
    EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10 (EIF-3 THETA) (EIF3 P167) (EIF3 P180) (EIF3 P185) (P162 PROTEIN) (CENTROSOMIN)
    centrosomin
    eIF-3-theta
    eIF3 p167
    eIF3 p180
    eIF3 p185
    eukaryotic translation initiation factor 3, subunit 10 (theta)
    p162

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010123.3 → NP_034253.3  eukaryotic translation initiation factor 3 subunit A

      See identical proteins and their annotated locations for NP_034253.3

      Status: VALIDATED

      Source sequence(s)
      AC163019, AK013070, AK145132, AK162784, U14172
      Consensus CDS
      CCDS38035.1
      UniProtKB/Swiss-Prot
      E9QQ50, P23116, Q60697, Q62162
      Related
      ENSMUSP00000025955.7, ENSMUST00000025955.8
      Conserved Domains (5) summary
      smart00753
      Location:426 → 498
      PAM; PCI/PINT associated module
      pfam05750
      Location:882 → 1111
      Rubella_Capsid; Rubella capsid protein
      cd16269
      Location:650 → 661
      GBP_C; coiled coil [structural motif]
      cl19219
      Location:643 → 737
      DUF342; Protein of unknown function (DUF342)
      cl20817
      Location:566 → 685
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60749554..60779131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23116.5 GenPept UniProtKB/Swiss-Prot:P23116

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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