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    Ei24 etoposide induced 2.4 mRNA [ Mus musculus (house mouse) ]

    Gene ID: 13663, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ei24provided by MGI
    Official Full Name
    etoposide induced 2.4 mRNAprovided by MGI
    Primary source
    MGI:MGI:108090
    See related
    Ensembl:ENSMUSG00000062762 AllianceGenome:MGI:108090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIG8
    Summary
    Predicted to enable importin-alpha family protein binding activity. Acts upstream of or within several processes, including cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of protein import into nucleus. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 47.4), bladder adult (RPKM 40.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A4; 9 20.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36690449..36708630, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36779153..36797334, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene checkpoint kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E709 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene predicted gene, 26787 Neighboring gene predicted gene 27219 Neighboring gene STARR-seq mESC enhancer starr_23786 Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene STARR-seq mESC enhancer starr_23787 Neighboring gene Pbx/knotted 1 homeobox 2 Neighboring gene predicted gene, 34652

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EI24 alleviates renal interstitial fibrosis through inhibition of epithelial-mesenchymal transition and fibroblast activation. Mao Y, et al. FASEB J, 2021 Jan. PMID 33368642
    2. Autophagy-related protein EI24 delays the development of pulmonary fibrosis by promoting autophagy. Zhang X, et al. Life Sci, 2021 Jan 1. PMID 33127511
    3. EI24 tethers endoplasmic reticulum and mitochondria to regulate autophagy flux. Yuan L, et al. Cell Mol Life Sci, 2020 Apr. PMID 31332481
    4. An analysis of an interactome for apoptosis factor, Ei24/PIG8, using the inducible expression system and shotgun proteomics. Bahk YY, et al. J Proteome Res, 2010 Oct 1. PMID 20731388
    5. Effect of EI24 expression on the tumorigenesis of Apc(Min/+) colorectal cancer mouse model. Nam TW, et al. Biochem Biophys Res Commun, 2019 Jul 5. PMID 31097220

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EI24 alleviates renal interstitial fibrosis through inhibition of epithelial-mesenchymal transition and fibroblast activation.
      Title: EI24 alleviates renal interstitial fibrosis through inhibition of epithelial-mesenchymal transition and fibroblast activation.
    2. Autophagy-related protein EI24 delays the development of pulmonary fibrosis by promoting autophagy.
      Title: Autophagy-related protein EI24 delays the development of pulmonary fibrosis by promoting autophagy.
    3. The Ei24 plays no significant role in colon cancer caused by the substitutional mutation of Apc in mice.
      Title: Effect of EI24 expression on the tumorigenesis of Apc(Min/+) colorectal cancer mouse model.
    4. This study shows that the autophagy process is inhibited in EI24-deficient primary pancreatic beta cells.
      Title: EI24 tethers endoplasmic reticulum and mitochondria to regulate autophagy flux.
    5. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic beta-cell survival
      Title: Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival.
    6. Findings establish EI24 as a critical suppressor of tumor progression.
      Title: EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity.
    7. Ei24 can bind specifically to IMPbeta1 and IMPalpha2 to impede their normal role in nuclear import.
      Title: The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.
    8. Ei24 is a novel E2F1 target gene contributing to the survival of p53-deficient cells upon UVC irradiation and thus may have a potential significance as a therapeutic target of certain chemotherapy for treating p53-deficient tumors.
      Title: Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation.
    9. Ei24 is a regulator of the RINCK1-PKCalpha-EGFR signaling pathway in the development of skin-cancer.
      Title: Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice.
    10. Ei24 is an essential autophagy gene and plays an important role in clearance of aggregate-prone proteins in neurons and hepatocytes.
      Title: The p53-induced gene Ei24 is an essential component of the basal autophagy pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to UV-C IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    etoposide-induced protein 2.4
    Names
    p53-induced gene 8 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199494.2 → NP_001186423.2  etoposide-induced protein 2.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC155921
      Consensus CDS
      CCDS22973.2
      UniProtKB/Swiss-Prot
      Q3T9X1, Q3TVX9, Q3UGS7, Q61070
      UniProtKB/TrEMBL
      A0A0R4J250
      Related
      ENSMUSP00000159090.2, ENSMUST00000238932.2
      Conserved Domains (1) summary
      pfam07264
      Location:120 → 254
      EI24; Etoposide-induced protein 2.4 (EI24)

    2. NM_007915.6 → NP_031941.2  etoposide-induced protein 2.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC155921
      Consensus CDS
      CCDS22973.2
      UniProtKB/Swiss-Prot
      Q3T9X1, Q3TVX9, Q3UGS7, Q61070
      UniProtKB/TrEMBL
      A0A0R4J250
      Related
      ENSMUSP00000132270.4, ENSMUST00000163192.11
      Conserved Domains (1) summary
      pfam07264
      Location:120 → 254
      EI24; Etoposide-induced protein 2.4 (EI24)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      36690449..36708630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61070.3 GenPept UniProtKB/Swiss-Prot:Q61070

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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