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    Efs embryonal Fyn-associated substrate [ Mus musculus (house mouse) ]

    Gene ID: 13644, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Efsprovided by MGI
    Official Full Name
    embryonal Fyn-associated substrateprovided by MGI
    Primary source
    MGI:MGI:105311
    See related
    Ensembl:ENSMUSG00000022203 AllianceGenome:MGI:105311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables SH3 domain binding activity. Predicted to be involved in actin filament reorganization; cell migration; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Used to study Crohn's disease. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 32.5), ovary adult (RPKM 23.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Efs in Genome Data Viewer
    Location:
    14 C3; 14 27.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55154087..55164222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54916543..54926788, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene BCL2-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E754 Neighboring gene poly(A) binding protein, nuclear 1 Neighboring gene solute carrier family 22 (organic cation transporter), member 17 Neighboring gene STARR-seq mESC enhancer starr_36750 Neighboring gene interleukin 25 Neighboring gene CKLF-like MARVEL transmembrane domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation. Donlin LT, et al. Mol Cell Biol, 2005 Dec. PMID 16314525, Free PMC Article
    2. Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs. Ishino M, et al. Oncogene, 1997 Oct 2. PMID 9349509
    3. Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Ishino M, et al. Oncogene, 1995 Dec 7. PMID 8570184
    4. Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. Danzl NM, et al. J Exp Med, 2010 May 10. PMID 20404100, Free PMC Article
    5. Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. Polte TR, et al. J Biol Chem, 1997 Feb 28. PMID 9038154

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sin-deficient mice exhibit exaggerated immune responses characterized by enhanced cytokine secretion and T-cell-dependent antibody production.
      Title: Deficiency in expression of the signaling protein Sin/Efs leads to T-lymphocyte activation and mucosal inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    embryonal Fyn-associated substrate
    Names
    SRC-interacting protein
    signal-integrating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424432.1 → NP_001411361.1  embryonal Fyn-associated substrate isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025533
      UniProtKB/TrEMBL
      A0A2I3BRP5

    2. NM_001424433.1 → NP_001411362.1  embryonal Fyn-associated substrate isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025533

    3. NM_001424434.1 → NP_001411363.1  embryonal Fyn-associated substrate isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025533

    4. NM_010112.5 → NP_034242.2  embryonal Fyn-associated substrate isoform 1

      See identical proteins and their annotated locations for NP_034242.2

      Status: VALIDATED

      Source sequence(s)
      CT025533
      Consensus CDS
      CCDS36925.1
      UniProtKB/Swiss-Prot
      Q64355, Q8BSX4
      UniProtKB/TrEMBL
      Q8K0F6
      Related
      ENSMUSP00000022813.7, ENSMUST00000022813.8
      Conserved Domains (2) summary
      cd12003
      Location:8 → 70
      SH3_EFS; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Embryonal Fyn-associated Substrate
      cl13463
      Location:371 → 555
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55154087..55164222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64355.2 GenPept UniProtKB/Swiss-Prot:Q64355

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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