Efnb3 ephrin B3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Efnb3provided by MGI
Official Full Name: ephrin B3provided by MGI
Primary source: MGI:MGI:109196
See related: Ensembl:ENSMUSG00000003934 AllianceGenome:MGI:109196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epl8; EFL-6; ELF-3; Elk-L3; LERK-8; NLERK-2
Summary: Predicted to enable ephrin receptor binding activity. Involved in negative regulation of axonogenesis and trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission. Acts upstream of or within T cell costimulation; adult walking behavior; and axon choice point recognition. Located in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study movement disease. Orthologous to human EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 44.0), whole brain E14.5 (RPKM 38.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.8 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69444918..69452428, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69554092..69561150, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer.
Title: Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer.
EphA2 mAb treatment could partially inhibit LPSinduced inactivation of EphBEphrin B3 signalling, while Ephrin B3 overexpression could abrogate LPSinduced activation of EphA2Ephrin A1 signalling. EphB1/Ephrin B3 signalling may antagonise the EphA2/Ephrin A1dependent pathway following LPS treatment
Title: Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury.
Data suggest that molecules in the erythropoietin-producing hepatocellular receptor B family (EPHB) / ephrinB (EFNB) signalling pathways, specifically ephrin B3 and GRIP1, are involved blood pressure regulation.
Title: The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility.
Data reveal that ephrinB2 and ephrinB3 signaling is required to control progenitor identities in the ventral spinal cord.
Title: Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord.
an autonomous receptor-like role for ephrin-B reverse signaling in the tangential migration of interneurons into the neocortex using ephrin-B (EfnB1/B2/B3) conditional triple mutant (TM(lz)) mice, is reported.
Title: Autonomous and non-autonomous roles for ephrin-B in interneuron migration.
ephrin B3/EphB2 are obvious candidates for driving the Syk-dependent repulsive response.
Title: Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway.
The Eph/ephrin-B3-mediated heterotypic or homotypic cell interactions between thymocytes and thymic epithelial cells (TECs), or between TECs and themselves, contribute to the early maturation of MTS20(+) TECs.
Title: Eph/ephrin-B-mediated cell-to-cell interactions govern MTS20(+) thymic epithelial cell development.
Findings suggest that EphrinB3 may be a relevant target for promoting remyelination in demyelinating disease
Title: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination.
The morphological and behavioural abnormalities in ephrin-B3 mutant mice are rescued by conditional knock-in of wild-type ephrin-B3 during the critical period when axon targeting and fear responses are initiated.
Title: Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour.
ephrin-B3 specifies the synaptic localization of PSD-95 and likely links the synaptic stability of PSD-95 to changes in neuronal activity
Title: Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (9) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Efnb3 (e-PCR), detects polymorphism
- UniSTS:495878

Efnb3 (e-PCR), detects polymorphism
- UniSTS:266984

Efnb3 (e-PCR), detects polymorphism
- UniSTS:506877

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ephrin-B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.