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    Efna2 ephrin A2 [ Mus musculus (house mouse) ]

    Gene ID: 13637, updated on 21-Apr-2024

    Summary

    Official Symbol
    Efna2provided by MGI
    Official Full Name
    ephrin A2provided by MGI
    Primary source
    MGI:MGI:102707
    See related
    Ensembl:ENSMUSG00000003070 AllianceGenome:MGI:102707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Elf1; Epl6; CEK7L; Eplg6; Lerk6
    Summary
    Enables ephrin receptor binding activity. Involved in bone remodeling; ephrin receptor signaling pathway; and osteoclast differentiation. Predicted to be located in neuromuscular junction and perikaryon. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and limb. Orthologous to human EFNA2 (ephrin A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 20.0), whole brain E14.5 (RPKM 18.4) and 16 other tissues See more
    Orthologs
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    Genomic context

    Location:
    10 C1; 10 39.72 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80015316..80025844)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80179482..80190010)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2949 Neighboring gene STARR-positive B cell enhancer ABC_E576 Neighboring gene cold inducible RNA binding protein Neighboring gene family with sequence similarity 174, member C Neighboring gene STARR-positive B cell enhancer ABC_E3898 Neighboring gene PWWP domain containing 3A, DNA repair factor Neighboring gene nuclear encoded tRNA pheylalanine 3 (anticodon GAA)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bone remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bone remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ephrin-A2
    Names
    CEK7-ligand
    EPH related receptor tyrosine kinase ligand 6
    ephrin A6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007909.3NP_031935.3  ephrin-A2 precursor

      See identical proteins and their annotated locations for NP_031935.3

      Status: VALIDATED

      Source sequence(s)
      AC159999, AK140544, CF740879
      Consensus CDS
      CCDS24013.1
      UniProtKB/Swiss-Prot
      P52801
      UniProtKB/TrEMBL
      Q3USB4
      Related
      ENSMUSP00000003154.6, ENSMUST00000003154.7
      Conserved Domains (1) summary
      cd10425
      Location:31167
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80015316..80025844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)