Dyrk1b dual-specificity tyrosine phosphorylation regulated kinase 1b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dyrk1bprovided by MGI
Official Full Name: dual-specificity tyrosine phosphorylation regulated kinase 1bprovided by MGI
Primary source: MGI:MGI:1330302
See related: Ensembl:ENSMUSG00000002409 AllianceGenome:MGI:1330302
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mirk
Summary: Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within myoblast fusion. Predicted to be located in chromosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in olfactory epithelium. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 39.4), thymus adult (RPKM 16.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 16.67 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (27878880..27896896)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28179447..28197910)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response.
Title: Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response.
DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
Title: DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.
Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
Title: Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
we demonstrated that Anxa1, Anxa2, and Dyrk1b are upregulated at both the transcriptional and translational levels by the overexpression of GAS1
Title: Annexin A1, Annexin A2, and Dyrk 1B are upregulated during GAS1-induced cell cycle arrest.
Through the activation of DYRK1B, Hedgehog signaling facilitates microtubule-dependent processes such as intracellular mitochondrial transport, mesenchymal cell polarization or directed cell migration.
Title: DYRK1B regulates Hedgehog-induced microtubule acetylation.
results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
Title: Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.
Cirp functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b.
Title: Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice.
BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk
Title: G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.
Mirk may function together with GSK3beta to assist cell arrest by destabilizing cyclin D1.
Title: Mirk/dyrk1B kinase destabilizes cyclin D1 by phosphorylation at threonine 288.
p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase
Title: The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 1B

Names: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b

NP_001033046.1

EC 2.7.12.1

NP_001258299.1

EC 2.7.12.1

NP_034222.1

EC 2.7.12.1

XP_006539589.1

EC 2.7.12.1

XP_006539590.1

EC 2.7.12.1

XP_030097944.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037957.4 → NP_001033046.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

See identical proteins and their annotated locations for NP_001033046.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform p69, also known as isoform b.

Source sequence(s)

AC141883

Consensus CDS

CCDS21037.1

UniProtKB/Swiss-Prot

Q3UFR5, Q70UR5, Q9EPM2, Q9Z188

Related

ENSMUSP00000083064.7, ENSMUST00000085901.13

Conserved Domains (2) summary

smart00220
Location:111 → 431

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:97 → 436

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_001271370.2 → NP_001258299.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p75

See identical proteins and their annotated locations for NP_001258299.1

Status: VALIDATED

Description

Transcript Variant: This variant (4), uses an alternate 5' structure, compared to variant 1. This difference causes translation initiation at an upstream AUG and results in an isoform (p75), also known as isoform c, that has a longer N-terminus, compared to isoform p69.

Source sequence(s)

AC141883

Consensus CDS

CCDS85251.1

UniProtKB/Swiss-Prot

Q9Z188

Related

ENSMUSP00000133431.3, ENSMUST00000172467.8

Conserved Domains (2) summary

smart00220
Location:171 → 491

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:157 → 496

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_010092.3 → NP_034222.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

See identical proteins and their annotated locations for NP_034222.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform p65, also known as isoform a, which is shorter than isoform p69.

Source sequence(s)

AC141883

Consensus CDS

CCDS57532.1

UniProtKB/Swiss-Prot

Q9Z188

Related

ENSMUSP00000133719.2, ENSMUST00000172761.8

Conserved Domains (2) summary

smart00220
Location:111 → 391

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:97 → 396

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

27878880..27896896

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242084.2 → XP_030097944.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

Conserved Domains (1) summary

cd14226
Location:97 → 408

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
XM_006539526.4 → XP_006539589.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

Conserved Domains (2) summary

PHA03378
Location:3 → 147

PHA03378; EBNA-3B; Provisional

cd14226
Location:157 → 468

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
XM_006539527.5 → XP_006539590.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

Conserved Domains (2) summary

PHA03378
Location:3 → 147

PHA03378; EBNA-3B; Provisional

cd14226
Location:157 → 456

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1