Dvl3 dishevelled segment polarity protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dvl3provided by MGI
Official Full Name: dishevelled segment polarity protein 3provided by MGI
Primary source: MGI:MGI:108100
See related: Ensembl:ENSMUSG00000003233 AllianceGenome:MGI:108100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: b2b2866Clo
Summary: Enables protein-macromolecule adaptor activity. Involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway via JNK cascade. Acts upstream of or within cochlea morphogenesis; outflow tract septum morphogenesis; and planar cell polarity pathway involved in neural tube closure. Located in cytoplasm. Part of Wnt signalosome. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 25.9), CNS E14 (RPKM 23.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 12.46 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (20335694..20352763)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (20516949..20534013)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation.
Title: Presenilin-2 knock-In mice show severe depressive behavior via DVL3 downregulation.
TLR4 activation promotes Wnt3a-Dvl3 signaling.
Title: TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling.
Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites at least in part, through regulation of EZH2 protein expression and through the DVL3/beta-catenin axis.
Title: Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites.
Dvl-2 and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb
Title: Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.
Dvl3 is important for IPMK to access substrates and generate IP5, activating down-stream signaling.
Title: Dvl3 translocates IPMK to the cell membrane in response to Wnt.
Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability.
Title: Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA.
Dvl2 and Dvl3 proteins were found to be localized to the apical side of the node cells, and their location was polarized to the posterior side of the cells before the posterior positioning of the basal body.
Title: Planar polarization of node cells determines the rotational axis of node cilia.
Dvl1, Dvl2 and Dvl3 are functionally redundant in cardiac outflow tract, cochlea, and neural tube development.
Title: Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells
Title: G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.
The expression of Dishevelleds in mammalian cells provide an estimate of the relative cellular abundance of each Dvl.
Title: Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S4388 (e-PCR)
- UniSTS:474139

Dvl3 (e-PCR), detects polymorphism
- UniSTS:142882

Dvl3 (e-PCR), detects polymorphism
- UniSTS:142883

NoName (e-PCR)
- UniSTS:532277

Dvl3 (e-PCR), detects polymorphism
- UniSTS:532277

AU048506 (e-PCR)
- UniSTS:144956

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Dvl3 (e-PCR), detects polymorphism
- UniSTS:508379

Dvl3 (e-PCR), detects polymorphism
- UniSTS:508380

Dvl3 (e-PCR), detects polymorphism
- UniSTS:532453

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in midbrain dopaminergic neuron differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within outflow tract septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in planar cell polarity pathway involved in neural tube closure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection arborization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: segment polarity protein dishevelled homolog DVL-3

Names: dishevelled 3, dsh homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347176.2 → NP_001334105.1 segment polarity protein dishevelled homolog DVL-3 isoform 2

Status: VALIDATED

Source sequence(s)

AC087898

Consensus CDS

CCDS84210.1

UniProtKB/TrEMBL

E9Q967

Related

ENSMUSP00000130925.2, ENSMUST00000171572.9

Conserved Domains (5) summary

smart00021
Location:1 → 82

DAX; Domain present in Dishevelled and axin

cd00992
Location:247 → 334

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:413 → 496

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:97 → 245

Dishevelled; Dishevelled specific domain

pfam12316
Location:500 → 706

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
NM_001416758.1 → NP_001403687.1 segment polarity protein dishevelled homolog DVL-3 isoform 3

Status: VALIDATED

Source sequence(s)

AC087898
NM_001416759.1 → NP_001403688.1 segment polarity protein dishevelled homolog DVL-3 isoform 4

Status: VALIDATED

Source sequence(s)

AC087898
NM_001416760.1 → NP_001403689.1 segment polarity protein dishevelled homolog DVL-3 isoform 5

Status: VALIDATED

Source sequence(s)

AC087898

UniProtKB/TrEMBL

E9Q150

Related

ENSMUSP00000126082.2, ENSMUST00000171774.2
NM_007889.4 → NP_031915.2 segment polarity protein dishevelled homolog DVL-3 isoform 1

See identical proteins and their annotated locations for NP_031915.2

Status: VALIDATED

Source sequence(s)

AC087898

Consensus CDS

CCDS37287.1

UniProtKB/Swiss-Prot

G5E820, Q61062

Related

ENSMUSP00000003318.6, ENSMUST00000003318.13

Conserved Domains (5) summary

smart00021
Location:1 → 82

DAX; Domain present in Dishevelled and axin

cd00992
Location:247 → 334

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:413 → 496

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:97 → 245

Dishevelled; Dishevelled specific domain

pfam12316
Location:500 → 706

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RNA

NR_184391.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC087898

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

20335694..20352763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521780.4 → XP_006521843.1 segment polarity protein dishevelled homolog DVL-3 isoform X1

Conserved Domains (5) summary

smart00021
Location:1 → 82

DAX; Domain present in Dishevelled and axin

cd00992
Location:246 → 333

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd04438
Location:412 → 495

DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...

pfam02377
Location:97 → 244

Dishevelled; Dishevelled specific domain

pfam12316
Location:499 → 705

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal