Adam18 a disintegrin and metallopeptidase domain 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam18provided by MGI
Official Full Name: a disintegrin and metallopeptidase domain 18provided by MGI
Primary source: MGI:MGI:105986
See related: Ensembl:ENSMUSG00000031552 AllianceGenome:MGI:105986
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dtgn3; Tmdc3; Adam27; tMDCIII
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during early stages of spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Expression: Restricted expression toward testis adult (RPKM 35.4) See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 12.82 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (25092262..25164771, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (24602246..24674755, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

D1S3698 (e-PCR)
- UniSTS:474276

D8Mit3 (e-PCR), detects polymorphism
- UniSTS:131512

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 18

Names: disintegrin 3; disintegrin and metalloproteinase domain-containing protein 27; transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010084.2 → NP_034214.2 disintegrin and metalloproteinase domain-containing protein 18 preproprotein

See identical proteins and their annotated locations for NP_034214.2

Status: REVIEWED

Source sequence(s)

AC114602, AC138355, AK076633, BY099176

Consensus CDS

CCDS22195.1

UniProtKB/Swiss-Prot

Q60621, Q80Y08, Q9R157

UniProtKB/TrEMBL

A6H649

Related

ENSMUSP00000033957.6, ENSMUST00000033957.12

Conserved Domains (5) summary

smart00608
Location:475 → 613

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:182 → 374

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam00200
Location:396 → 472

Disintegrin; Disintegrin

pfam01421
Location:182 → 374

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:30 → 139

Pep_M12B_propep; Reprolysin family propeptide