U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Arid3a AT-rich interaction domain 3A [ Mus musculus (house mouse) ]

    Gene ID: 13496, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Arid3aprovided by MGI
    Official Full Name
    AT-rich interaction domain 3Aprovided by MGI
    Primary source
    MGI:MGI:1328360
    See related
    Ensembl:ENSMUSG00000019564 AllianceGenome:MGI:1328360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dri1; Dril1; Bright
    Summary
    Enables several functions, including chromatin binding activity; identical protein binding activity; and transcription coregulator activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and skin. Orthologous to human ARID3A (AT-rich interaction domain 3A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 13.2), testis adult (RPKM 6.1) and 25 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79762877..79790852)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79927043..79955018)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene KISS1 receptor Neighboring gene STARR-positive B cell enhancer ABC_E6878 Neighboring gene STARR-positive B cell enhancer ABC_E10625 Neighboring gene predicted gene, 40715 Neighboring gene STARR-positive B cell enhancer ABC_E10626 Neighboring gene STARR-seq mESC enhancer starr_27254 Neighboring gene STARR-positive B cell enhancer ABC_E1804 Neighboring gene WD repeat domain 18 Neighboring gene glutamate receptor, ionotropic, NMDA3B Neighboring gene transmembrane protein 259

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Arid3a is essential to execution of the first cell fate decision via direct embryonic and extraembryonic transcriptional regulation. Rhee C, et al. Genes Dev, 2014 Oct 15. PMID 25319825, Free PMC Article
    2. Transgenic mice expressing dominant-negative bright exhibit defects in B1 B cells. Nixon JC, et al. J Immunol, 2008 Nov 15. PMID 18981111, Free PMC Article
    3. A regulated nucleocytoplasmic shuttle contributes to Bright's function as a transcriptional activator of immunoglobulin genes. Kim D, et al. Mol Cell Biol, 2006 Mar. PMID 16507996, Free PMC Article
    4. Comprehensive analysis identified a reduction in ATP1A2 mediated by ARID3A in abdominal aortic aneurysm. Wang Q, et al. J Cell Mol Med, 2022 May. PMID 35441443, Free PMC Article
    5. A Role for the Transcription Factor Arid3a in Mouse B2 Lymphocyte Expansion and Peritoneal B1a Generation. Habir K, et al. Front Immunol, 2017. PMID 29114251, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis.
      Title: A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis.
    2. Comprehensive analysis identified a reduction in ATP1A2 mediated by ARID3A in abdominal aortic aneurysm.
      Title: Comprehensive analysis identified a reduction in ATP1A2 mediated by ARID3A in abdominal aortic aneurysm.
    3. Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.
      Title: Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation.
    4. Our data show that signals provided by thymic epithelial cells control thymic B cell development by up-regulating Let-7, suppressing Arid3a expression in intrathymic progenitor B cells to limit their proliferation during the neonatal to adult transition.
      Title: Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a.
    5. ARID3A is required for normal murine trophoblast development in vivo. The results reveal an essential, conserved function for ARID3A in mammalian placental development through regulation of both intrinsic and extrinsic developmental programs.
      Title: ARID3A is required for mammalian placenta development.
    6. identify the Arid3a transcription factor as a key target of Let-7, whose ectopic expression is sufficient to induce B-1 development in adult pro-B cells and whose silencing by knockdown blocks B-1 development in fetal pro-B cells.
      Title: Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a.
    7. These data reveal new functions for ARID3a in early hematopoiesis and suggest that knowledge regarding ARID3a levels in HSPCs could be informative for applications requiring transplantation of those cells.
      Title: Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells.
    8. identify Arid3a as a critical regulator of TE and placental development through execution of the commitment and differentiation phases of the first cell fate decision
      Title: Arid3a is essential to execution of the first cell fate decision via direct embryonic and extraembryonic transcriptional regulation.
    9. These data suggest a novel role for Bright in the normal development of mature B cell subsets and in autoantibody production
      Title: The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.
    10. these results place Bright/Arid3a on a select list of transcriptional regulators required to program both hematopoietic stem cell and lineage-specific differentiation.
      Title: The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    AT-rich interactive domain-containing protein 3A
    Names
    ARID domain-containing protein 3A
    AT rich interactive domain 3A (BRIGHT-like)
    AT rich interactive domain 3A (Bright like)
    B-cell regulator of IgH transcription
    dead ringer homolog 1
    dead ringer-like protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288625.1 → NP_001275554.1  AT-rich interactive domain-containing protein 3A isoform a

      See identical proteins and their annotated locations for NP_001275554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK141283, BP763961
      Consensus CDS
      CCDS23999.1
      UniProtKB/Swiss-Prot
      Q3U338, Q62431, Q80YP8
      Related
      ENSMUSP00000101015.2, ENSMUST00000105376.2
      Conserved Domains (1) summary
      cd16878
      Location:224 → 356
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    2. NM_001288626.1 → NP_001275555.1  AT-rich interactive domain-containing protein 3A isoform b

      See identical proteins and their annotated locations for NP_001275555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 2 aa shorter compared to isoform a.
      Source sequence(s)
      BC050925, BP763961, BY126533
      Consensus CDS
      CCDS78851.1
      UniProtKB/TrEMBL
      A0A0R4J1A7
      Related
      ENSMUSP00000101016.2, ENSMUST00000105377.8
      Conserved Domains (1) summary
      smart00501
      Location:244 → 336
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    3. NM_007880.4 → NP_031906.1  AT-rich interactive domain-containing protein 3A isoform a

      See identical proteins and their annotated locations for NP_031906.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK141283, BC050925, BP763961, BY126533
      Consensus CDS
      CCDS23999.1
      UniProtKB/Swiss-Prot
      Q3U338, Q62431, Q80YP8
      Related
      ENSMUSP00000019708.6, ENSMUST00000019708.12
      Conserved Domains (1) summary
      cd16878
      Location:224 → 356
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79762877..79790852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513202.5 → XP_006513265.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006513265.1

      UniProtKB/Swiss-Prot
      Q3U338, Q62431, Q80YP8
      Conserved Domains (1) summary
      cd16878
      Location:224 → 356
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins

    2. XM_006513201.5 → XP_006513264.1  AT-rich interactive domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006513264.1

      UniProtKB/Swiss-Prot
      Q3U338, Q62431, Q80YP8
      Conserved Domains (1) summary
      cd16878
      Location:224 → 356
      ARID_ARID3A; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3A (ARID3A) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62431.1 GenPept UniProtKB/Swiss-Prot:Q62431

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous