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    Dpep1 dipeptidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 13479, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Dpep1provided by MGI
    Official Full Name
    dipeptidase 1provided by MGI
    Primary source
    MGI:MGI:94917
    See related
    Ensembl:ENSMUSG00000019278 AllianceGenome:MGI:94917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBD; DPEP-1
    Summary
    Enables beta-lactamase activity and dipeptidase activity. Involved in several processes, including glutathione catabolic process; leukotriene metabolic process; and neutrophil chemotaxis. Predicted to be located in apical part of cell; cell junction; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in genitourinary system; incisor; and lung. Orthologous to human DPEP1 (dipeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 182.7), small intestine adult (RPKM 109.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 72.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123913069..123928551)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123186235..123201812)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57791 Neighboring gene predicted gene 4316 Neighboring gene charged multivesicular body protein 1A Neighboring gene ribosomal protein S12, pseudogene 9 Neighboring gene spermatogenesis associated 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Lau A, et al. Sci Adv, 2022 Feb 4. PMID 35108057, Free PMC Article
    2. Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver. Choudhury SR, et al. Cell, 2019 Aug 22. PMID 31442408
    3. Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. Habib GM, et al. Adv Exp Med Biol, 1999. PMID 10667344
    4. Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Habib GM, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560193, Free PMC Article
    5. Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase. Habib GM, et al. J Biol Chem, 1996 Jul 5. PMID 8663190

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
      Title: Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
    2. A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
      Title: A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
    3. Genetic ablation or functional peptide blocking of DPEP1 significantly reduced neutrophil recruitment to the lungs and liver and provided improved survival in models of endotoxemia.
      Title: Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver.
    4. Contrast-induced acute kidney injury is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1.
      Title: Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-lactamase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-lactamase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables modified amino acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antibiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leukotriene D4 catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukotriene metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidase 1
    Names
    MBD-1
    beta-lactamase
    dipeptidase 1 (renal)
    membrane bound dipeptidase type II
    membrane-bound dipeptidase 1
    microsomal dipeptidase
    renal dipeptidase
    NP_001403941.1
    NP_031902.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417012.1 → NP_001403941.1  dipeptidase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC163617
      UniProtKB/Swiss-Prot
      G5E824, P31428

    2. NM_007876.3 → NP_031902.2  dipeptidase 1 precursor

      See identical proteins and their annotated locations for NP_031902.2

      Status: VALIDATED

      Source sequence(s)
      AC163617
      Consensus CDS
      CCDS22750.1
      UniProtKB/Swiss-Prot
      G5E824, P31428
      UniProtKB/TrEMBL
      Q99LA8
      Related
      ENSMUSP00000019422.5, ENSMUST00000019422.6
      Conserved Domains (1) summary
      pfam01244
      Location:25 → 352
      Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123913069..123928551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31428.2 GenPept UniProtKB/Swiss-Prot:P31428

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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