Reep5 receptor accessory protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reep5provided by MGI
Official Full Name: receptor accessory protein 5provided by MGI
Primary source: MGI:MGI:1270152
See related: Ensembl:ENSMUSG00000005873 AllianceGenome:MGI:1270152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dp1; DP1/TB2; TB2/DP1
Summary: Located in endoplasmic reticulum tubular network. Is expressed in early conceptus; nervous system; pancreas; and secondary oocyte. Orthologous to human REEP5 (receptor accessory protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 93.0), subcutaneous fat pad adult (RPKM 90.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.57 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (34477938..34508044, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (34344885..34374991, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of receptor accessory protein 5 (REEP5) in mouse cardiac myocytes results in sarco-endoplasmic reticulum (SR/ER) membrane destabilization and luminal vacuolization along with decreased myocyte contractility and disrupted Ca(2+) cycling. Adeno-associated viral (AAV9)-induced REEP5 depletion in the mouse demonstrates cardiac dysfunction.
Title: REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects.
it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 were mediated successively by the PGD2-DP1 receptor, adenosine-A2A receptor, and GABA-GABAA receptor systems downstream of the FPR2.
Title: Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors.
PGD2 is produced in articular tissue during the development of collagen-induced arthritis and plays an antiinflammatory role, acting through the DP1 receptor.
Title: Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Reep5 (e-PCR), detects polymorphism
- UniSTS:498251

AI324241 (e-PCR)
- UniSTS:181092

AU022809 (e-PCR)
- UniSTS:181104

AW495741 (e-PCR)
- UniSTS:181105

RH125118 (e-PCR)
- UniSTS:161940

AU022809 (e-PCR)
- UniSTS:209363

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in junctional sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: receptor expression-enhancing protein 5

Names: GP106; deleted in polyposis 1; polyposis locus protein 1 homolog; protein TB2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.