Dlx3 distal-less homeobox 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlx3provided by MGI
Official Full Name: distal-less homeobox 3provided by MGI
Primary source: MGI:MGI:94903
See related: Ensembl:ENSMUSG00000001510 AllianceGenome:MGI:94903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlx-3
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and chromatin binding activity. Acts upstream of or within several processes, including odontoblast differentiation; odontogenesis of dentin-containing tooth; and placenta development. Located in nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 4.7), stomach adult (RPKM 3.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.01 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (95010943..95016122)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (95120117..95125296)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation.
Title: CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation.
Dlx3 Ubiquitination by Nuclear Mdm2 Is Essential for Dentinogenesis in Mice.
Title: Dlx3 Ubiquitination by Nuclear Mdm2 Is Essential for Dentinogenesis in Mice.
DLX3 regulates the expression of some components of myosin II complexes potentially involved in driving the movement of ameloblasts that leads to enamel rod decussation.
Title: Pleiotropic function of DLX3 in amelogenesis: from regulating pH and keratin expression to controlling enamel rod decussation.
DLX3 is a critical regulator of STAT3 signaling network that maintains skin homeostasis.
Title: DLX3-Dependent STAT3 Signaling in Keratinocytes Regulates Skin Immune Homeostasis.
DLX3 is indispensable for the regulation of ion transporters and carbonic anhydrases during the maturation stage of amelogenesis, exerting a crucial regulatory function on pH oscillations during enamel mineralization.
Title: DLX3-Dependent Regulation of Ion Transporters and Carbonic Anhydrases is Crucial for Enamel Mineralization.
ER-alpha regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3.
Title: Estrogen Receptor α Regulates Dlx3-Mediated Osteoblast Differentiation.
indicate that Distal-less-3 negatively regulates osteoclastic differentiation through microRNA-124
Title: DLX3 negatively regulates osteoclastic differentiation through microRNA-124.
our data show that DLX3 promotes the expression of the EMP genes Amelx, Enam, Klk4, and Odam in amelogenesis.
Title: Transcriptional factor DLX3 promotes the gene expression of enamel matrix proteins during amelogenesis.
Results suggest that Dlx3 is a novel target of PKA, and that PKA mediates BMP signaling during osteoblast differentiation, at least in part, by phosphorylating Dlx3 and modulating its stability and function.
Title: Protein kinase a phosphorylates Dlx3 and regulates the function of Dlx3 during osteoblast differentiation.
The DLX3 regulates transcription factors crucial for bone formation and DLX3 attenuates bone mass accrual to support bone homeostasis by osteogenic gene pathway regulation.
Title: DLX3 regulates bone mass by targeting genes supporting osteoblast differentiation and mineral homeostasis in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

PMC99823P1 (e-PCR)
- UniSTS:273687

Dlx3 (e-PCR), detects polymorphism
- UniSTS:506852

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein DLX-3

Names: DII C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010055.4 → NP_034185.1 homeobox protein DLX-3

See identical proteins and their annotated locations for NP_034185.1

Status: VALIDATED

Source sequence(s)

AL606480

Consensus CDS

CCDS25272.1

UniProtKB/Swiss-Prot

Q64205

UniProtKB/TrEMBL

Q78ZZ8, Q9QWH3

Related

ENSMUSP00000090443.6, ENSMUST00000092768.7

Conserved Domains (3) summary

pfam00046
Location:132 → 185

Homeobox; Homeobox domain

pfam12413
Location:27 → 107

DLL_N; Homeobox protein distal-less-like N terminal

cl27820
Location:109 → 224

Abdominal-A; Homeobox protein