Ctf1 cardiotrophin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctf1provided by MGI
Official Full Name: cardiotrophin 1provided by MGI
Primary source: MGI:MGI:105115
See related: Ensembl:ENSMUSG00000042340 AllianceGenome:MGI:105115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CT-1
Summary: Predicted to enable cytokine activity and leukemia inhibitory factor receptor binding activity. Acts upstream of or within neuron development. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and heart and pericardium. Used to study abdominal obesity-metabolic syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CTF1 (cardiotrophin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 16.6), ovary adult (RPKM 10.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 69.69 cM; 7 F3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127311872..127317360)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127712676..127718188)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis.
Title: Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis.
Cardiotrophin-1 contributes to metabolic adaptations through the regulation of lipid metabolism and to the fasting-induced fatty acid mobilization.
Title: Cardiotrophin-1 contributes to metabolic adaptations through the regulation of lipid metabolism and to the fasting-induced fatty acid mobilization.
Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression.
Title: Cardiotrophin-1 Deficiency Abrogates Atherosclerosis Progression.
Cardiotrophin-1 participates in the endogenous response that opposes renal damage by counteracting the inflammatory, apoptotic and fibrotic processes
Title: Cardiotrophin-1 opposes renal fibrosis in mice: Potential prevention of chronic kidney disease.
findings support the notion that cardiotrophin-1 (CT-1) is a critical regulator of inflammation and suggest that rCT-1 could be a molecule with potential therapeutic application in inflammatory conditions
Title: Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4-induced M2 macrophage polarization.
These results suggest that CT-1 may be a potent candidate for the early prevention and treatment of Alzheimer disease.
Title: The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice.
Identify cardiotrophin-1 as a powerful cytokine promoting mesenchymal stromal cell engraftment and thus improving cell therapy of the infarcted myocardium.
Title: In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells.
CT-1 mRNA levels in adipose tissue showed significant circadian fluctuations in young WT mice. Clock genes displayed a circadian rhythm in adipose tissue of both wild-type (WT) and CT-1-/- mice. However, the pattern was altered in CT-1-/- mice toward a lower percentage of the rhythm or lower amplitude, especially for Bmal1 and Clock.
Title: Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects.
Cardiotrophin-1 modulates the production of adipokines in vitro and in vivo, suggesting that the regulation of the secretory function of adipocytes could be involved in the metabolic actions of this cytokine.
Title: Cardiotrophin-1 Regulates Adipokine Production in 3T3-L1 Adipocytes and Adipose Tissue From Obese Mice.
Nuclear translocation of CT-1 regulates cardiomyogenesis of ES cells and involves calcium, NO, ROS as well as CT-1 regulated signaling pathways.
Title: Stimulation of cardiomyogenesis from mouse embryonic stem cells by nuclear translocation of cardiotrophin-1.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

U18366 (e-PCR)
- UniSTS:185734

Ctf1 (e-PCR), detects polymorphism
- UniSTS:502691

Ctf1 (e-PCR), detects polymorphism
- UniSTS:502694

U18366 (e-PCR)
- UniSTS:186279

PMC26660P1 (e-PCR)
- UniSTS:272345

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables leukemia inhibitory factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukemia inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cardiotrophin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301282.2 → NP_001288211.1 cardiotrophin-1 isoform 2

See identical proteins and their annotated locations for NP_001288211.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and coding region. These differences result in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC124507

Consensus CDS

CCDS85423.1

UniProtKB/TrEMBL

A0A0U1RNJ2

Related

ENSMUSP00000145586.2, ENSMUST00000206506.2

Conserved Domains (1) summary

cl21565
Location:22 → 187

LIF_OSM; LIF / OSM family
NM_001301283.2 → NP_001288212.1 cardiotrophin-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and coding region. These differences result in the use of an alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC124507

Conserved Domains (1) summary

cl21565
Location:21 → 186

LIF_OSM; LIF / OSM family
NM_001412288.1 → NP_001399217.1 cardiotrophin-1 isoform 4

Status: VALIDATED

Source sequence(s)

AC124507
NM_001412289.1 → NP_001399218.1 cardiotrophin-1 isoform 5

Status: VALIDATED

Source sequence(s)

AC124507
NM_001412290.1 → NP_001399219.1 cardiotrophin-1 isoform 6

Status: VALIDATED

Source sequence(s)

AC124507
NM_007795.3 → NP_031821.1 cardiotrophin-1 isoform 1

See identical proteins and their annotated locations for NP_031821.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC124507

Consensus CDS

CCDS21875.1

UniProtKB/Swiss-Prot

Q60753

UniProtKB/TrEMBL

Q541U3

Related

ENSMUSP00000049161.6, ENSMUST00000047393.7

Conserved Domains (1) summary

cl21565
Location:29 → 194

LIF_OSM; LIF / OSM family