Ctbp2 C-terminal binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctbp2provided by MGI
Official Full Name: C-terminal binding protein 2provided by MGI
Primary source: MGI:MGI:1201686
See related: Ensembl:ENSMUSG00000030970 AllianceGenome:MGI:1201686
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ribeye; Gtrgeo6; D7Ertd45e
Summary: Enables several functions, including retinoic acid receptor binding activity; transcription coactivator activity; and transcription corepressor activity. A structural constituent of presynaptic active zone. Involved in negative regulation of transcription, DNA-templated; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of chromatin binding activity; and positive regulation of retinoic acid receptor signaling pathway. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Part of transcription repressor complex. Is active in presynaptic active zone cytoplasmic component and presynaptic cytosol. Is expressed in several structures, including alimentary system; limb; lung; nervous system; and retina layer. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 16.7), CNS E14 (RPKM 16.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 76.32 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (132588727..132726048, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (132986998..133124009, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis.
Title: The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis.
Photoreceptor Compartment-Specific TULP1 Interactomes.
Title: Photoreceptor Compartment-Specific TULP1 Interactomes.
The corepressor CtBP2 is required for proper development of the mouse cerebral cortex.
Title: The corepressor CtBP2 is required for proper development of the mouse cerebral cortex.
MCRIP1 interferes with interactions of CtBP with the lung-enriched transcriptional repressors, Foxp1 and Foxp2, thereby preventing the recruitment of the CtBP co-repressor complex to the SP-B and SP-C promoters and maintaining them in an active chromatin state. Homozygous deficiency of Mcrip1 in mice causes fatal respiratory distress due to abnormal transcriptional repression of surfactant proteins.
Title: MCRIP1 promotes the expression of lung-surfactant proteins in mice by disrupting CtBP-mediated epigenetic gene silencing.
VGLL4 acted as an adaptor protein that enhanced the interaction between TEAD4 and CtBP2, and this TEAD4-VGLL4-CtBP2 ternary complex dynamically existed at the early stage of adipogenesis.
Title: The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex.
The authors postulate that RIBEYE disruption is partially compensated by several small active zone organization at each synaptic contact between inner hair cells and spiral ganglion neurons.
Title: The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
These findings suggest a suppressive function for Ctbp2 in reducing the protein level of beta-catenin, along with priming its position on core pluripotency genes to hinder beta-catenin deposition, which is central to commitment to the appropriate lineage.
Title: Ctbp2-mediated β-catenin regulation is required for exit from pluripotency.
studies revealed a new epigenetic pathway in the control of IL-2 production in systemic lupus erythematosus whereby low levels of miR-200a-3p accumulate the binding of the ZEB1-CtBP2 complex to the IL-2 promoter and suppress IL-2 production
Title: Downregulation of miR-200a-3p, Targeting CtBP2 Complex, Is Involved in the Hypoproduction of IL-2 in Systemic Lupus Erythematosus-Derived T Cells.
Our results show that RIBEYE is essential for synaptic ribbons as such, and may organize presynaptic nano-domains that position release-ready synaptic vesicles adjacent to Ca(2+) channels
Title: How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release.
Ctbp2 preoccupies regions in active genes with the NuRD complex in undifferentiated ESCs that are directed toward H3K27me3 by PRC2 to induce stable silencing, which is pivotal for natural lineage commitment.
Title: Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235793

BF401944 (e-PCR)
- UniSTS:245546

D7Ertd45e (e-PCR), detects polymorphism
- UniSTS:167520

RH124584 (e-PCR)
- UniSTS:161406

T25625 (e-PCR)
- UniSTS:125630

D7Dcr55 (e-PCR), detects polymorphism
- UniSTS:546507

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of presynaptic active zone	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription coregulator binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle docking	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle docking	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in white fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in photoreceptor ribbon synapse	IC Inferred by Curator more info	PubMed
is_active_in photoreceptor ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in photoreceptor ribbon synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic active zone cytoplasmic component	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C-terminal-binding protein 2

Names: gene trap ROSA b-geo 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170744.2 → NP_001164215.1 C-terminal-binding protein 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC119806

Consensus CDS

CCDS52417.1

UniProtKB/Swiss-Prot

P56546

Related

ENSMUSP00000130294.2, ENSMUST00000169570.8

Conserved Domains (2) summary

COG0111
Location:593 → 903

SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]

cd05299
Location:577 → 895

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001347623.2 → NP_001334552.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1. Variants 3 and 13-19 all encode the same isoform (3).

Source sequence(s)

AC119806, AC138624

Consensus CDS

CCDS90344.1

UniProtKB/TrEMBL

Q3UIX8, Q91YZ2

Conserved Domains (1) summary

cd05299
Location:9 → 327

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
NM_001412294.1 → NP_001399223.1 C-terminal-binding protein 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC119806
NM_001412295.1 → NP_001399224.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412296.1 → NP_001399225.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412297.1 → NP_001399226.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412298.1 → NP_001399227.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412299.1 → NP_001399228.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412300.1 → NP_001399229.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412301.1 → NP_001399230.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412302.1 → NP_001399231.1 C-terminal-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5
NM_001412303.1 → NP_001399232.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/TrEMBL

Q91YZ2
NM_001412304.1 → NP_001399233.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/TrEMBL

Q91YZ2
NM_001412305.1 → NP_001399234.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/TrEMBL

Q91YZ2
NM_001412306.1 → NP_001399235.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/TrEMBL

Q91YZ2
NM_001412307.1 → NP_001399236.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/TrEMBL

Q91YZ2

Related

ENSMUSP00000127448.2, ENSMUST00000166439.8
NM_001412308.1 → NP_001399237.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/TrEMBL

Q91YZ2
NM_001412309.1 → NP_001399238.1 C-terminal-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC119806, AC138624

UniProtKB/TrEMBL

Q91YZ2
NM_009980.5 → NP_034110.1 C-terminal-binding protein 2 isoform 2

See identical proteins and their annotated locations for NP_034110.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Variants 2 and 5-12 all encode the same isoform (2).

Source sequence(s)

AC119806, AC138624

Consensus CDS

CCDS21930.1

UniProtKB/Swiss-Prot

O54855, O88462, P56546

UniProtKB/TrEMBL

Q3UGL5, Q3UIX8

Related

ENSMUSP00000033269.9, ENSMUST00000033269.15

Conserved Domains (1) summary

cd05299
Location:34 → 352

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

132588727..132726048 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152630.1 → XP_036008523.1 C-terminal-binding protein 2 isoform X2

UniProtKB/TrEMBL

Q3UIX8, Q91YZ2

Conserved Domains (1) summary

cd05299
Location:9 → 327

CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor