Csk c-src tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cskprovided by MGI
Official Full Name: c-src tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:88537
See related: Ensembl:ENSMUSG00000032312 AllianceGenome:MGI:88537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p50CSK
Summary: Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within negative regulation of cell population proliferation. Located in cell-cell junction. Is expressed in several structures, including Peyer's patch; central nervous system; genitourinary system; gut; and liver and biliary system. Orthologous to human CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 65.3), thymus adult (RPKM 53.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.18 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57533929..57560758, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57626646..57653631, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
Title: STAP-2 negatively regulates BCR-mediated B cell activation by recruiting tyrosine-protein kinase CSK to LYN.
eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin.
Title: eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin.
CSK promotes innate immune response to DNA virus by phosphorylating MITA.
Title: CSK promotes innate immune response to DNA virus by phosphorylating MITA.
Data show that c-Src is present on the Golgi and ER of acinar cells and its activity regulates transit of amylase along the secretory pathway.
Title: c-Src regulates cargo transit via the Golgi in pancreatic acinar cells.
These data suggest that inhibition of GABAergic inhibitory postsynaptic currents by morphine involves a beta-arr2/c-Src mediated mechanism.
Title: Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.
This study establishes Csk and CD148 as critical molecular switches controlling the thrombotic and hemostatic capacity of platelets and reveals cell-intrinsic mechanisms that prevent pathological thrombosis from occurring.
Title: Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
The results suggest that Csk in Intestinal epithelial cells plays important roles in the regulation of the intestinal epithelial barrier function and protection against colitis.
Title: Role of Csk in intestinal epithelial barrier function and protection against colitis.
N1-Src was implicated in L1-CAM signalling as PDN1 inhibited L1-CAM dependent neurite elongation in cerebellar granule neurons (CGNs).
Title: Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM.
identify a physiological pathway by which blood pressure is regulated, in which the insufficiency of Csk induces aldosterone production with zonal specificity in the adrenal glands, increasing sodium reabsorption and plasma volume and thus resulting in hypertension.
Title: Csk Regulates Blood Pressure by Controlling the Synthetic Pathways of Aldosterone.
Our results have uncovered a previously unknown role of c-Src tyrosine kinase in regulating interneuron function in the brain and identified a novel mechanism by which TASK-1 channels are activated in neurons.
Title: Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csk (e-PCR), detects polymorphism
- UniSTS:480304

16.MMHAP70FLF1.seq (e-PCR)
- UniSTS:123318

Csk (e-PCR), detects polymorphism
- UniSTS:527296

AW212630 (e-PCR)
- UniSTS:179906

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to peptide hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell activation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase CSK

Names: C-Src kinase; protein-tyrosine kinase MPK-2

NP_001291690.1

EC 2.7.10.2

NP_001398570.1

EC 2.7.10.2

NP_001398571.1

EC 2.7.10.2

NP_001398572.1

EC 2.7.10.2

NP_001398573.1

EC 2.7.10.2

NP_031809.2

EC 2.7.10.2

XP_011240961.1

EC 2.7.10.2

XP_030099899.1

EC 2.7.10.2

XP_036010486.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304761.2 → NP_001291690.1 tyrosine-protein kinase CSK

See identical proteins and their annotated locations for NP_001291690.1

Status: VALIDATED

Source sequence(s)

AC122528

Consensus CDS

CCDS23228.1

UniProtKB/Swiss-Prot

P41241, Q03143, Q80WU4, Q8VCW1

UniProtKB/TrEMBL

Q3UVH2

Related

ENSMUSP00000150590.2, ENSMUST00000215396.2

Conserved Domains (3) summary

cd05082
Location:188 → 443

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase

cd09937
Location:78 → 175

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
NM_001411641.1 → NP_001398570.1 tyrosine-protein kinase CSK

Status: VALIDATED

Source sequence(s)

AC122528

UniProtKB/Swiss-Prot

P41241, Q03143, Q80WU4, Q8VCW1
NM_001411642.1 → NP_001398571.1 tyrosine-protein kinase CSK

Status: VALIDATED

Source sequence(s)

AC122528

UniProtKB/Swiss-Prot

P41241, Q03143, Q80WU4, Q8VCW1
NM_001411643.1 → NP_001398572.1 tyrosine-protein kinase CSK

Status: VALIDATED

Source sequence(s)

AC122528

UniProtKB/Swiss-Prot

P41241, Q03143, Q80WU4, Q8VCW1
NM_001411644.1 → NP_001398573.1 tyrosine-protein kinase CSK

Status: VALIDATED

Source sequence(s)

AC122528

UniProtKB/Swiss-Prot

P41241, Q03143, Q80WU4, Q8VCW1
NM_007783.4 → NP_031809.2 tyrosine-protein kinase CSK

See identical proteins and their annotated locations for NP_031809.2

Status: VALIDATED

Source sequence(s)

AC122528

Consensus CDS

CCDS23228.1

UniProtKB/Swiss-Prot

P41241, Q03143, Q80WU4, Q8VCW1

UniProtKB/TrEMBL

Q3UVH2

Related

ENSMUSP00000034863.7, ENSMUST00000034863.8

Conserved Domains (3) summary

cd05082
Location:188 → 443

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase

cd09937
Location:78 → 175

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

57533929..57560758 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154593.1 → XP_036010486.1 tyrosine-protein kinase CSK isoform X1

UniProtKB/Swiss-Prot

P41241, Q03143, Q80WU4, Q8VCW1

UniProtKB/TrEMBL

Q3UVH2

Related

ENSMUSP00000150984.2, ENSMUST00000217314.2

Conserved Domains (3) summary

cd05082
Location:188 → 443

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase

cd09937
Location:78 → 175

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
XM_030244039.1 → XP_030099899.1 tyrosine-protein kinase CSK isoform X2

Conserved Domains (1) summary

cd05082
Location:16 → 271

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase
XM_011242659.3 → XP_011240961.1 tyrosine-protein kinase CSK isoform X3

Conserved Domains (2) summary

cd09937
Location:78 → 154

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase