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    Cryz crystallin, zeta [ Mus musculus (house mouse) ]

    Gene ID: 12972, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cryzprovided by MGI
    Official Full Name
    crystallin, zetaprovided by MGI
    Primary source
    MGI:MGI:88527
    See related
    Ensembl:ENSMUSG00000028199 AllianceGenome:MGI:88527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sez9
    Summary
    Predicted to enable several functions, including NADPH binding activity; NADPH:quinone reductase activity; and mRNA 3'-UTR binding activity. Predicted to be involved in protein homotetramerization and xenobiotic catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human CRYZ (crystallin zeta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 72.1), placenta adult (RPKM 16.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 H4; 3 79.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (154302348..154328819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (154596711..154623182)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09339 Neighboring gene predicted gene, 40186 Neighboring gene STARR-positive B cell enhancer ABC_E9581 Neighboring gene STARR-seq mESC enhancer starr_09341 Neighboring gene tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E4607 Neighboring gene STARR-seq mESC enhancer starr_09345 Neighboring gene STARR-seq mESC enhancer starr_09346 Neighboring gene predicted gene 20389 Neighboring gene glutamate rich 3 Neighboring gene TNNI3 interacting kinase Neighboring gene STARR-seq mESC enhancer starr_09349 Neighboring gene leucine rich repeat containing 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability. Szutkowska M, et al. Kidney Int, 2009 Oct. PMID 19657324
    2. Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. Gonzalez P, et al. Mol Biol Evol, 1994 Mar. PMID 8170370
    3. Recruitment of enzymes as lens structural proteins. Wistow G, et al. Science, 1987 Jun 19. PMID 3589669
    4. Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells. Alam G, et al. Pflugers Arch, 2020 Nov. PMID 32914211
    5. Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. Rao PV, et al. Biochemistry, 1997 May 6. PMID 9154917

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells.
      Title: Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells.
    2. induction of zeta-crystallin by an acid pH plays an important role in preventing BSC1 mRNA decay
      Title: Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables NADPH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADPH:quinone reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH:quinone reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    quinone oxidoreductase
    Names
    NADPH:quinone reductase
    quinone reductase
    zeta-crystallin
    NP_001344601.1
    NP_001344602.1
    NP_001344603.1
    NP_001344604.1
    NP_001344605.1
    NP_034098.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357672.1 → NP_001344601.1  quinone oxidoreductase

      Status: VALIDATED

      Source sequence(s)
      AC107667, AC164292, BC043076
      Consensus CDS
      CCDS17927.1
      UniProtKB/Swiss-Prot
      P47199, Q62508, Q99L63
      UniProtKB/TrEMBL
      Q3UYY0, Q80XR3
      Conserved Domains (1) summary
      cd08253
      Location:8 → 331
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

    2. NM_001357673.1 → NP_001344602.1  quinone oxidoreductase

      Status: VALIDATED

      Source sequence(s)
      AC107667, AC164292, BC043076
      Consensus CDS
      CCDS17927.1
      UniProtKB/Swiss-Prot
      P47199, Q62508, Q99L63
      UniProtKB/TrEMBL
      Q3UYY0, Q80XR3
      Conserved Domains (1) summary
      cd08253
      Location:8 → 331
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

    3. NM_001357674.1 → NP_001344603.1  quinone oxidoreductase

      Status: VALIDATED

      Source sequence(s)
      AC107667, AC164292, BC043076
      Consensus CDS
      CCDS17927.1
      UniProtKB/Swiss-Prot
      P47199, Q62508, Q99L63
      UniProtKB/TrEMBL
      Q3UYY0, Q80XR3
      Conserved Domains (1) summary
      cd08253
      Location:8 → 331
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

    4. NM_001357675.1 → NP_001344604.1  quinone oxidoreductase

      Status: VALIDATED

      Source sequence(s)
      AC107667, AC164292, BC043076
      Consensus CDS
      CCDS17927.1
      UniProtKB/Swiss-Prot
      P47199, Q62508, Q99L63
      UniProtKB/TrEMBL
      Q3UYY0, Q80XR3
      Conserved Domains (1) summary
      cd08253
      Location:8 → 331
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

    5. NM_001357676.1 → NP_001344605.1  quinone oxidoreductase

      Status: VALIDATED

      Source sequence(s)
      AC107667, AC164292, BC043076
      Consensus CDS
      CCDS17927.1
      UniProtKB/Swiss-Prot
      P47199, Q62508, Q99L63
      UniProtKB/TrEMBL
      Q3UYY0, Q80XR3
      Conserved Domains (1) summary
      cd08253
      Location:8 → 331
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

    6. NM_009968.4 → NP_034098.1  quinone oxidoreductase

      See identical proteins and their annotated locations for NP_034098.1

      Status: VALIDATED

      Source sequence(s)
      AK134281, BB618817, BC043076
      Consensus CDS
      CCDS17927.1
      UniProtKB/Swiss-Prot
      P47199, Q62508, Q99L63
      UniProtKB/TrEMBL
      Q3UYY0, Q80XR3
      Related
      ENSMUSP00000029850.9, ENSMUST00000029850.15
      Conserved Domains (1) summary
      cd08253
      Location:8 → 331
      zeta_crystallin; Zeta-crystallin with NADP-dependent quinone reductase activity (QOR)

    RNA

    1. NR_151773.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107667, AC164292, BC043076

    2. NR_151774.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107667, AC164292, BC043076

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      154302348..154328819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47199.1 GenPept UniProtKB/Swiss-Prot:P47199

    Gene LinkOut

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