Cr1l complement C3b/C4b receptor 1 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cr1lprovided by MGI
Official Full Name: complement C3b/C4b receptor 1 likeprovided by MGI
Primary source: MGI:MGI:88513
See related: Ensembl:ENSMUSG00000016481 AllianceGenome:MGI:88513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcp; Crry; mCRY
Summary: Predicted to enable complement receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in malaria. Orthologous to several human genes including CR1L (complement C3b/C4b receptor 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 23.9), placenta adult (RPKM 23.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 98.43 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (194781019..194813878, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (195098711..195131570, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction.
Title: Expression dynamics of Crry at the implantation sites in normal pregnancy and response against miscarriage induction.
Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones.
Title: Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones.
Our study uncovers a damaging effect of complement C3 or downstream complement activation in glaucoma, and it establishes AAV2.CR2-Crry as a viable therapeutic strategy to target pathogenic C3-mediated complement activation in the glaucomatous retina
Title: Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
CRRY role in the retinal epithelium and photoreceptor degeneration
Title: Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.
Factor H and Crry are critical for regulating complement activation at distinct anatomic sites within the kidney.
Title: Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.
this study has provided direct evidence for a role of Crry in controlling spontaneous alternative pathway complement activation on renal tubular epithelial cells.
Title: Tissue-specific deletion of Crry from mouse proximal tubular epithelial cells increases susceptibility to renal ischemia-reperfusion injury.
HBx can up-regulate CD59 and Crry expression in podocytes through activating the P38 pathway.
Title: [Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes].
Crry costimulation enhanced the in vitro expansion of natural Treg cells while maintaining their phenotypic and suppressive properties. Crry-expanded Treg cells decreasing antigen-dependent secretion of cytokines.
Title: Complement regulatory protein Crry/p65 costimulation expands natural treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.
Stmn2 and the chromosome 14 Rarb region, but not Cr1 or Clu or Picalm, have roles in prion disease.
Title: The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry or CR2-factor H.
Title: Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M23529 (e-PCR)
- UniSTS:124941

Crry (e-PCR), detects polymorphism
- UniSTS:257040

Crry (e-PCR), detects polymorphism
- UniSTS:141405

Crry-ps (e-PCR), detects polymorphism
- UniSTS:141406

BB228973 (e-PCR)
- UniSTS:207276

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables complement component C3b binding	ISO Inferred from Sequence Orthology more info
enables complement component C3b receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C4b binding	ISO Inferred from Sequence Orthology more info
enables complement component C4b receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell mediated immunity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within complement activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female pregnancy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of complement activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of complement activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of complement activation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of complement activation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: complement component receptor 1-like protein

Names: complement component (3b/4b) receptor 1-like; complement receptor related protein; complement regulatory protein Crry; protein p65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355060.1 → NP_001341989.1 complement component receptor 1-like protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC139206, AK134226

Consensus CDS

CCDS87948.1

UniProtKB/Swiss-Prot

E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328

UniProtKB/TrEMBL

A0A0A6YY75

Related

ENSMUSP00000142309.2, ENSMUST00000193094.6

Conserved Domains (1) summary

cl27761
Location:42 → 295

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_001355061.1 → NP_001341990.1 complement component receptor 1-like protein isoform 3

Status: VALIDATED

Source sequence(s)

AC139206, AK160440

Consensus CDS

CCDS87947.1

UniProtKB/TrEMBL

A0A0A6YXN9

Related

ENSMUSP00000142069.2, ENSMUST00000194111.6

Conserved Domains (1) summary

cl27761
Location:4 → 257

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
NM_013499.2 → NP_038527.2 complement component receptor 1-like protein isoform 1 precursor

See identical proteins and their annotated locations for NP_038527.2

Status: VALIDATED

Source sequence(s)

AI098173, AK004825, CA491482

Consensus CDS

CCDS15641.1

UniProtKB/Swiss-Prot

E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328

Related

ENSMUSP00000074902.7, ENSMUST00000075451.12

Conserved Domains (4) summary

cd00033
Location:165 → 232

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00032
Location:237 → 293

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)

PHA02927
Location:42 → 295

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:42 → 98

Sushi; Sushi repeat (SCR repeat)