Bcar1 breast cancer anti-estrogen resistance 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcar1provided by MGI
Official Full Name: breast cancer anti-estrogen resistance 1provided by MGI
Primary source: MGI:MGI:108091
See related: Ensembl:ENSMUSG00000031955 AllianceGenome:MGI:108091
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cas; Crkas
Summary: Predicted to enable protein domain specific binding activity and protein kinase binding activity. Involved in G protein-coupled receptor signaling pathway and platelet-derived growth factor receptor signaling pathway. Acts upstream of or within cell migration. Located in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 90.6), small intestine adult (RPKM 67.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 57.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (112437106..112470481, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (111710474..111743849, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands.
Title: p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands.
Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Title: Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.
Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis.
Title: Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis.
Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
Title: Kif1c regulates osteoclastic bone resorption as a downstream molecule of p130Cas.
These results indicate that the mechanosensor p130Cas controls both oligodensrocyte morphogenesis and maturation
Title: Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas.
The authors identify p130Cas as an effector molecule of Src and show that the phosphorylated p130Cas is elevated in murine and cellular models of Spinal and bulbar muscular atrophy.
Title: Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.
a novel interaction of p130Cas with Ser/Thr kinase PKN3, is reported.
Title: The interaction of p130Cas with PKN3 promotes malignant growth.
p130Cas is an important regulator of epidermal cell fate and homeostasis
Title: Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.
CAS localizes to the force transduction layer of focal adhesions and mechanical stress stabilizes CAS in focal adhesions.
Title: The role of focal adhesion anchoring domains of CAS in mechanotransduction.
Data suggest that the first LD motif (LD1; leucine-rich motif) of paxillin binds to the CCHD (C-terminal region of Cas family homology domain) of p130Cas/Bcar1 (in a 1:1 stoichiometry with Kd approximately 4.2 uM); p130Cas/Bcar1 CCHD is stabilized by forming complex with paxillin LD1; these studies utilized chicken paxillin and mouse p130Cas/Bcar1. (p130Cas/Bcar1 = breast cancer anti-estrogen resistance protein 1)
Title: Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Crkas (e-PCR), detects polymorphism
- UniSTS:141400

AI385681 (e-PCR)
- UniSTS:179826

NoName (e-PCR)
- UniSTS:236003

Bcar1 (e-PCR), detects polymorphism
- UniSTS:531429

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in antigen receptor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to endothelin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hepatocyte growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in endothelin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
colocalizes_with plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: breast cancer anti-estrogen resistance protein 1

Names: CRK-associated substrate; p130 Cas; p130cas; v-crk-associated tyrosine kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198839.1 → NP_001185768.1 breast cancer anti-estrogen resistance protein 1 isoform A

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform A. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.

Source sequence(s)

AK167352, BC057578

Consensus CDS

CCDS85616.1

UniProtKB/TrEMBL

Q3TJB5, Q3TXP6

Related

ENSMUSP00000148364.2, ENSMUST00000212349.2

Conserved Domains (3) summary

cd11552
Location:458 → 614

Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cd12001
Location:4 → 71

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1

pfam12026
Location:659 → 868

DUF3513; Domain of unknown function (DUF3513)
NM_009954.3 → NP_034084.2 breast cancer anti-estrogen resistance protein 1 isoform B

See identical proteins and their annotated locations for NP_034084.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, and encodes isoform B. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.

Source sequence(s)

BC057578, BY733553

Consensus CDS

CCDS52675.1

UniProtKB/Swiss-Prot

Q60869, Q61140, Q6PFF9

UniProtKB/TrEMBL

Q3TIT7

Related

ENSMUSP00000129584.3, ENSMUST00000166232.4

Conserved Domains (3) summary

cd11552
Location:458 → 614

Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module

cd12001
Location:5 → 71

SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1

pfam12026
Location:659 → 868

DUF3513; Domain of unknown function (DUF3513)