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    Cpeb1 cytoplasmic polyadenylation element binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 12877, updated on 21-Apr-2024

    Summary

    Official Symbol
    Cpeb1provided by MGI
    Official Full Name
    cytoplasmic polyadenylation element binding protein 1provided by MGI
    Primary source
    MGI:MGI:108442
    See related
    Ensembl:ENSMUSG00000025586 AllianceGenome:MGI:108442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpeb; mCPEB; Cpe-bp1; mCpeb-1
    Summary
    Enables mRNA 3'-UTR AU-rich region binding activity and translation repressor activity, mRNA regulatory element binding. Involved in cellular response to amino acid stimulus; cellular response to hypoxia; and negative regulation of cytoplasmic translation. Acts upstream of or within regulation of neuronal synaptic plasticity; regulation of translation; and synaptonemal complex assembly. Located in several cellular components, including cytoplasm; meiotic spindle; and nucleus. Is expressed in brain; early embryo; olfactory epithelium; and reproductive system. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 9.8), frontal lobe adult (RPKM 9.6) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    7 D3; 7 45.71 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80996774..81105207, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81347026..81458001, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 8A Neighboring gene translocase of inner mitochondrial membrane 17a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88496762-88496958 Neighboring gene ribosomal protein S17 Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12) pseudogene Neighboring gene ribosomal protein L7A, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_19364 Neighboring gene adaptor-related protein complex 3, beta 2 subunit Neighboring gene cDNA sequence BC048679

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC159179

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA regulatory element binding translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA regulatory element binding translation repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation factor activity, RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation at synapse, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of translation at synapse, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of messenger ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    cytoplasmic polyadenylation element-binding protein 1
    Names
    CPE-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252525.1NP_001239454.1  cytoplasmic polyadenylation element-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK077799, BC125476, BY720025, CO803180
      Consensus CDS
      CCDS57557.1
      UniProtKB/TrEMBL
      F6X7Z3, Q059Z2
      Related
      ENSMUSP00000137079.2, ENSMUST00000178892.3
      Conserved Domains (4) summary
      cd12723
      Location:309416
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:427512
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:504559
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1307
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    2. NM_001252526.1NP_001239455.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK077799, BC125476, BC144948, BY720025, CO803180
      UniProtKB/TrEMBL
      F6X7Z3
      Related
      ENSMUSP00000120139.2, ENSMUST00000130310.8
      Conserved Domains (4) summary
      cd12723
      Location:308410
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:421506
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:498553
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1306
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    3. NM_001357107.1NP_001344036.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus, compared to isoform 1. Variants 4 and 12-16 all encode the same isoform (4).
      Source sequence(s)
      AC162897, CO803180
      UniProtKB/TrEMBL
      F6X7Z3
      Conserved Domains (4) summary
      pfam16366
      Location:423478
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1231
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
      cd12723
      Location:233335
      RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:346429
      RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    4. NM_001412273.1NP_001399202.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    5. NM_001412274.1NP_001399203.1  cytoplasmic polyadenylation element-binding protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    6. NM_001412275.1NP_001399204.1  cytoplasmic polyadenylation element-binding protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    7. NM_001412276.1NP_001399205.1  cytoplasmic polyadenylation element-binding protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    8. NM_001412277.1NP_001399206.1  cytoplasmic polyadenylation element-binding protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    9. NM_001412278.1NP_001399207.1  cytoplasmic polyadenylation element-binding protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    10. NM_001412279.1NP_001399208.1  cytoplasmic polyadenylation element-binding protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC162897
    11. NM_001412280.1NP_001399209.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    12. NM_001412281.1NP_001399210.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    13. NM_001412282.1NP_001399211.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162897
    14. NM_001412283.1NP_001399212.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    15. NM_001412284.1NP_001399213.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC162897
    16. NM_001412285.1NP_001399214.1  cytoplasmic polyadenylation element-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    17. NM_001412286.1NP_001399215.1  cytoplasmic polyadenylation element-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC162897, AC167120, AC169082
    18. NM_001412287.1NP_001399216.1  cytoplasmic polyadenylation element-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC162897
    19. NM_007755.5NP_031781.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_031781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK077799, BC144948, BY720025, CO803180, Y08260
      Consensus CDS
      CCDS40007.1
      UniProtKB/Swiss-Prot
      P70166, Q8C5P9
      UniProtKB/TrEMBL
      F6X7Z3
      Related
      ENSMUSP00000095936.4, ENSMUST00000098331.10
      Conserved Domains (4) summary
      cd12723
      Location:308415
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:426511
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:503558
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1306
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80996774..81105207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242061.2XP_030097921.1  cytoplasmic polyadenylation element-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      F6X7Z3
      Conserved Domains (4) summary
      cd12723
      Location:309399
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:410495
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:487513
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1307
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    2. XM_011250788.4XP_011249090.1  cytoplasmic polyadenylation element-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      F6X7Z3
      Conserved Domains (4) summary
      cd12723
      Location:347437
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:448533
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:525580
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48345
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    3. XM_036152627.1XP_036008520.1  cytoplasmic polyadenylation element-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      F6X7Z3
      Conserved Domains (4) summary
      pfam16366
      Location:524579
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:44344
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
      cd12723
      Location:346436
      RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:447530
      RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    4. XM_011250785.4XP_011249087.1  cytoplasmic polyadenylation element-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      F6X7Z3
      Conserved Domains (4) summary
      cd12723
      Location:346453
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:464549
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:541596
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48344
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    5. XM_011250784.4XP_011249086.1  cytoplasmic polyadenylation element-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      F6X7Z3
      Conserved Domains (4) summary
      cd12723
      Location:347454
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:465550
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:542597
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:48345
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    6. XM_011250790.4XP_011249092.1  cytoplasmic polyadenylation element-binding protein 1 isoform X8

      See identical proteins and their annotated locations for XP_011249092.1

      UniProtKB/TrEMBL
      F6X7Z3
      Conserved Domains (4) summary
      cd12723
      Location:233340
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:351436
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:428483
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1231
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    7. XM_011250792.3XP_011249094.1  cytoplasmic polyadenylation element-binding protein 1 isoform X10

      Conserved Domains (4) summary
      cd12723
      Location:179286
      RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      cd12725
      Location:297382
      RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
      pfam16366
      Location:374429
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      pfam16368
      Location:1177
      CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus