Comp cartilage oligomeric matrix protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Compprovided by MGI
Official Full Name: cartilage oligomeric matrix proteinprovided by MGI
Primary source: MGI:MGI:88469
See related: Ensembl:ENSMUSG00000031849 AllianceGenome:MGI:88469
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TSP5
Summary: Enables BMP binding activity; integrin binding activity; and protease binding activity. Acts upstream of or within several processes, including animal organ development; chondrocyte proliferation; and vasculature development. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including connective tissue; embryo mesenchyme; notochord; placenta; and skeletal system. Used to study multiple epiphyseal dysplasia and pseudoachondroplasia. Human ortholog(s) of this gene implicated in carpal tunnel syndrome; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 93.6) and limb E14.5 (RPKM 39.4) See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.15 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (70826186..70834721)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70373548..70382066)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways.
Title: COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways.
COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-beta Signaling Pathway.
Title: COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-β Signaling Pathway.
Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis.
Title: Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis.
COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure.
Title: COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure.
Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis.
Title: Cartilage oligomeric matrix protein fine-tunes disturbed flow-induced endothelial activation and atherogenesis.
Mutant COMP shapes growth and development of skull and facial structures in mice and humans.
Title: Mutant COMP shapes growth and development of skull and facial structures in mice and humans.
COMP regulation of BMPR2 appears to have an important role in controlling hypoxia-elicited changes in pulmonary artery superoxide and its potential regulation of contractile phenotype proteins.
Title: Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia.
COMP-prohibitin 2 interaction in mitochondria plays an important role in maintaining the contractile phenotype of Vascular smooth muscle cells by regulating mitochondrial oxidative phosphorylation.
Title: COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity.
While identifying the cellular pathologic mechanisms underlying the murine mutant (MT)-COMP model of pseudoachondroplasia, increased midline-1 (MID1) expression and mammalian target of rapamycin complex 1 (mTORC1) signaling was found.
Title: Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies.
COMP N-terminus directly interacted with the EGF11-12 domain of Notch1 and activated Notch1 signaling, as evidenced by co-immunoprecipitation and mammalian two-hybrid assay. In conclusion, COMP served as a potential ligand of Notch1, thereby driving embryonic stem cell (ESC)-vascular smooth muscle cells (VSMCs) differentiation.
Title: Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info	PubMed
enables vitamin D binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cartilage homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within growth plate cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within growth plate cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within limb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within musculoskeletal movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hemostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to unfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tendon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vascular associated smooth muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vascular associated smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cartilage oligomeric matrix protein

Names: thrombospondin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016685.2 → NP_057894.2 cartilage oligomeric matrix protein precursor

See identical proteins and their annotated locations for NP_057894.2

Status: VALIDATED

Source sequence(s)

AC158553, AF033530, BY328097, CJ324165

Consensus CDS

CCDS22367.1

UniProtKB/Swiss-Prot

G3X8Q4, Q9R0G6

UniProtKB/TrEMBL

Q8VI54

Related

ENSMUSP00000003659.8, ENSMUST00000003659.9

Conserved Domains (7) summary

smart00179
Location:178 → 216

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:125 → 160

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00001
Location:395 → 416

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:299 → 334

TSP3; TSP3 repeat_long [structural motif]

pfam02412
Location:300 → 334

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:544 → 741

TSP_C; Thrombospondin C-terminal region

cd16077
Location:29 → 71

TSP-5cc; Coiled coil region of thrombospondin-5 (TSP-5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

70826186..70834721

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153742.1 → XP_036009635.1 cartilage oligomeric matrix protein isoform X1

UniProtKB/TrEMBL

Q8VI54

Conserved Domains (8) summary

smart00179
Location:178 → 216

EGF_CA; Calcium-binding EGF-like domain

cd00054
Location:125 → 160

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00001
Location:395 → 416

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:299 → 334

TSP3; TSP3 repeat_long [structural motif]

cd16077
Location:29 → 71

TSP-5cc; Coiled coil region of thrombospondin-5 (TSP-5)

pfam02412
Location:299 → 334

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:544 → 694

TSP_C; Thrombospondin C-terminal region

NF033845
Location:311 → 542

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_006509539.2 → XP_006509602.1 cartilage oligomeric matrix protein isoform X2

UniProtKB/TrEMBL

Q8VI54

Conserved Domains (6) summary

smart00179
Location:67 → 105

EGF_CA; Calcium-binding EGF-like domain

sd00001
Location:284 → 305

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:188 → 223

TSP3; TSP3 repeat_long [structural motif]

pfam00008
Location:18 → 49

EGF; EGF-like domain

pfam02412
Location:188 → 223

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:433 → 630

TSP_C; Thrombospondin C-terminal region