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    Camp cathelicidin antimicrobial peptide [ Mus musculus (house mouse) ]

    Gene ID: 12796, updated on 21-Apr-2024

    Summary

    Official Symbol
    Campprovided by MGI
    Official Full Name
    cathelicidin antimicrobial peptideprovided by MGI
    Primary source
    MGI:MGI:108443
    See related
    Ensembl:ENSMUSG00000038357 AllianceGenome:MGI:108443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLP; Cnlp; MCLP; CAP18; Cramp; FALL39
    Summary
    This gene encodes a member of the cathelicidin family of antimicrobial peptides that play an important role in the defense against microbial infection. The encoded preproprotein undergoes proteolytic processing to generate a mature polypeptide before secretion by host cells such as neutrophils, epithelial cells and macrophages. Mice lacking the encoded protein exhibit increased susceptibility to group A streptococcus and Escherichia coli infections. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in liver E18 (RPKM 317.5), liver E14.5 (RPKM 37.3) and 2 other tissues See more
    Orthologs
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    Genomic context

    Location:
    9 F2; 9 59.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109676445..109678524, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109847377..109849456, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 6 Neighboring gene STARR-positive B cell enhancer ABC_E9775 Neighboring gene predicted gene, 39427 Neighboring gene STARR-seq mESC enhancer starr_25239 Neighboring gene STARR-positive B cell enhancer ABC_E31 Neighboring gene cell division cycle 25A Neighboring gene microRNA 7089

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chronic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytolysis by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response in mucosa ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within killing by host of symbiont cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within killing by host of symbiont cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of process of another organism ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to yeast ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in specific granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cathelicidin antimicrobial peptide
    Names
    cathelin-like protein
    cathelin-related antimicrobial peptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009921.2NP_034051.2  cathelicidin antimicrobial peptide precursor

      See identical proteins and their annotated locations for NP_034051.2

      Status: REVIEWED

      Source sequence(s)
      BC120754, BY582734, U43409
      Consensus CDS
      CCDS52934.1
      UniProtKB/Swiss-Prot
      P51437, Q0VB78
      UniProtKB/TrEMBL
      Q3TZ97
      Related
      ENSMUSP00000107653.3, ENSMUST00000112022.5
      Conserved Domains (2) summary
      pfam00666
      Location:2995
      Cathelicidins; Cathelicidin
      pfam12153
      Location:140165
      CAP18_C; LPS binding domain of CAP18 (C terminal)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109676445..109678524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)