Cnga2 cyclic nucleotide gated channel alpha 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnga2provided by MGI
Official Full Name: cyclic nucleotide gated channel alpha 2provided by MGI
Primary source: MGI:MGI:108040
See related: Ensembl:ENSMUSG00000005864 AllianceGenome:MGI:108040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CNG2; Cnca; Cncg4; OCNC1
Summary: This gene encodes a transmembrane protein that is the main subunit of the nucleotide-gated olfactory ion channel, which plays a key role in transducing chemosensory signal resulting from hydrogen sulphide exposure. Signaling pathways mediated by this gene operate in the cilia of type B cells. Knock out of this gene affects development of the olfactory epithelium and olfactory bulb. [provided by RefSeq, Aug 2022]
Expression: Biased expression in genital fat pad adult (RPKM 1.9), lung adult (RPKM 0.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.15 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (71035455..71053824)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (71991849..72010218)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Cnga2 knock-out mice there was an overproduction of Amyloid beta protein, tau hyper-phosphorylation, and behavioral abnormalities.
Title: Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes.
This study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings.
Title: Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice.
Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.
Title: Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.
CNGA2 channels contribute to ATP-induced non-capacitative calcium influx in vascular endothelial cells. It is likely that ATP acts through P2Y(1)receptors and adenylyl cyclases to stimulate CNGA2.
Title: CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells.
Mediates epinephrine-induced endothelial calcium influx and subsequent vascular dilation.
Title: Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels.
CNGA2 channels play a key role in adenosine-induced endothelial Ca(2+) influx and vasorelaxation
Title: CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells.
CNGA2 channels are not necessary for either the response of GnRH-1 neurons to cAMP increases or the basal rhythmic activity of GnRH-1 neurons.
Title: Gonadotropin-releasing hormone-1 neuronal activity is independent of cyclic nucleotide-gated channels.
Mice lacking functional CNGA2, which is required for odor-evoked MOE signaling, fail to mate or fight, suggesting a broad and essential role for the MOE in regulating these behaviors.
Title: Deficits in sexual and aggressive behaviors in Cnga2 mutant mice.
Function in the nose is unique to the main population of olfactory sensory neurons.
Title: Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands.
important for odor discrimination and adaptation in behaving mice
Title: Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cyclic nucleotide-gated olfactory channel

Names: CNG channel alpha-2; cyclic nucleotide gated channel 4; cyclic nucleotide-gated cation channel 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410247.1 → NP_001397176.1 cyclic nucleotide-gated olfactory channel

Status: REVIEWED

Source sequence(s)

AL731693

UniProtKB/Swiss-Prot

Q62398, Q80XH6

UniProtKB/TrEMBL

A3KGE1
NM_007724.3 → NP_031750.2 cyclic nucleotide-gated olfactory channel

See identical proteins and their annotated locations for NP_031750.2

Status: REVIEWED

Source sequence(s)

AK132574, BC048775

Consensus CDS

CCDS30184.1

UniProtKB/Swiss-Prot

Q62398, Q80XH6

UniProtKB/TrEMBL

A3KGE1

Related

ENSMUSP00000006020.8, ENSMUST00000006020.8

Conserved Domains (4) summary

cd00038
Location:456 → 572

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:142 → 384

Ion_trans; Ion transport protein

pfam16526
Location:572 → 639

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

cl18962
Location:417 → 470

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

71035455..71053824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527761.1 → XP_006527824.1 cyclic nucleotide-gated olfactory channel isoform X1

See identical proteins and their annotated locations for XP_006527824.1

UniProtKB/Swiss-Prot

Q62398, Q80XH6

UniProtKB/TrEMBL

A3KGE1

Conserved Domains (4) summary

cd00038
Location:456 → 572

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:142 → 384

Ion_trans; Ion transport protein

pfam16526
Location:572 → 639

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

cl18962
Location:417 → 470

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...