Cnbp cellular nucleic acid binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnbpprovided by MGI
Official Full Name: cellular nucleic acid binding proteinprovided by MGI
Primary source: MGI:MGI:88431
See related: Ensembl:ENSMUSG00000030057 AllianceGenome:MGI:88431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf9; Cnbp1
Summary: Predicted to enable nucleic acid binding activity and translation regulator activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription by RNA polymerase II. Located in cytosol; endoplasmic reticulum; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 105.5), liver E14 (RPKM 104.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 39.13 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (87819597..87828088, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (87842615..87851106, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating beta-catenin signaling.
Title: Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling.
Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
Title: Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
The findings reveal CNBP as a key transcriptional regulator of tumor-promoting target genes to control tumor cell biology.
Title: CNBP controls tumor cell biology by regulating tumor-promoting gene expression.
these findings identify CNBP as important regulator of c-Rel-dependent IL-12beta gene transcription and Th1 immunity.
Title: CNBP controls IL-12 gene transcription and Th1 immunity.
A loss of Cnbp disturbs myofibrillar sarcomeric organization at birth. Surviving homozygous Cnbp KO mice develop muscle atrophy at a young age. The skeletal muscle phenotype in heterozygous Cnbp KO mice was milder, but they developed severe muscle wasting at an advanced age.
Title: Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy.
our study suggests that CNBP could maintain testicular development by inhibiting the Wnt/beta-catenin pathway, particularly by influencing Sertoli cells.
Title: Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice.
A G-rich motif in the lncRNA Braveheart interacts with Cnbp to specify the cardiovascular lineage.
Title: A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage.
data support a role for CNBP as a critical transcription factor and a key regulator of the prolonged expression of sustained cytokine IL-6 during persistent LPS stimulation or Gram-negative bacterial infection
Title: CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6.
CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression.
Title: Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development.
expression of APP(Swe) in murine tissue induces a decrease in CNBP expression.
Title: APP(DeltaNL695) expression in murine tissue downregulates CNBP expression.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Targeted (3)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132805 (e-PCR)
- UniSTS:216088

RH124749 (e-PCR)
- UniSTS:161571

Cnbp (e-PCR), detects polymorphism
- UniSTS:141362

UniSTS:224585 (e-PCR)
- UniSTS:224585

PMC15869P1 (e-PCR)
- UniSTS:271437

SHGC-77307 (e-PCR)
- UniSTS:25935

Cnbp (e-PCR), detects polymorphism
- UniSTS:547432

Cnbp (e-PCR), detects polymorphism
- UniSTS:479151

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables G-quadruplex DNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G-quadruplex DNA formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CCHC-type zinc finger nucleic acid binding protein

Names: cellular nucleic acid binding protein 1; zinc finger protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109745.1 → NP_001103215.1 CCHC-type zinc finger nucleic acid binding protein isoform 2

See identical proteins and their annotated locations for NP_001103215.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1.

Source sequence(s)

AK078427, AK144740, AK159810, CJ088264

UniProtKB/TrEMBL

Q3U5V2

Conserved Domains (1) summary

PTZ00368
Location:47 → 165

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
NM_001109746.1 → NP_001103216.1 CCHC-type zinc finger nucleic acid binding protein isoform 3

See identical proteins and their annotated locations for NP_001103216.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has two alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (3) differs in the middle region and has identical N- and C-termini, as compared to isoform 1.

Source sequence(s)

AK144740, AK151961, CJ088264

Consensus CDS

CCDS85092.1

UniProtKB/TrEMBL

Q3U935

Related

ENSMUSP00000109249.3, ENSMUST00000113619.8

Conserved Domains (1) summary

PTZ00368
Location:47 → 164

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
NM_001347325.1 → NP_001334254.1 CCHC-type zinc finger nucleic acid binding protein isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (4) lacks one amino acid, as compared to isoform 1.

Source sequence(s)

AK075760, AK144740, AK147157, CJ088264

Consensus CDS

CCDS85091.1

UniProtKB/TrEMBL

D3YYF6, Q3ULK8

Related

ENSMUSP00000145274.2, ENSMUST00000204653.3

Conserved Domains (1) summary

PTZ00368
Location:54 → 171

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
NM_001355195.1 → NP_001342124.1 CCHC-type zinc finger nucleic acid binding protein isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1. Isoforms 2 and 5 are the same length but have distinct sequences.

Source sequence(s)

AK144740, AK147157, CJ088264

Consensus CDS

CCDS90085.1

UniProtKB/TrEMBL

A0A0N4SVS6

Related

ENSMUSP00000145227.2, ENSMUST00000204890.3

Conserved Domains (1) summary

PTZ00368
Location:48 → 165

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
NM_013493.3 → NP_038521.1 CCHC-type zinc finger nucleic acid binding protein isoform 1

See identical proteins and their annotated locations for NP_038521.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK144740, BC058723, CJ088264

Consensus CDS

CCDS51841.1

UniProtKB/Swiss-Prot

P53996, Q80Y06, Q8BP23

UniProtKB/TrEMBL

Q5QJQ9

Related

ENSMUSP00000032138.9, ENSMUST00000032138.15

Conserved Domains (1) summary

PTZ00368
Location:54 → 172

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional