Ccr7 C-C motif chemokine receptor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccr7provided by MGI
Official Full Name: C-C motif chemokine receptor 7provided by MGI
Primary source: MGI:MGI:103011
See related: Ensembl:ENSMUSG00000037944 AllianceGenome:MGI:103011
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7
Summary: Enables C-C chemokine receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of leukocyte chemotaxis; and regulation of cytokine production. Acts upstream of or within chemotaxis; homeostasis of number of cells; and immune response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and white fat. Used to study Sjogren's syndrome. Orthologous to human CCR7 (C-C motif chemokine receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 74.8), thymus adult (RPKM 70.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.92 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (99035025..99045903, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (99144199..99155077, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of the effect of CCR7 on the microenvironment of mouse oral squamous cell carcinoma by single-cell RNA sequencing technology.
Title: Analysis of the effect of CCR7 on the microenvironment of mouse oral squamous cell carcinoma by single-cell RNA sequencing technology.
CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.
Title: CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance.
CCL21/CCR7 axis regulates demyelination and vascular cognitive impairment in a mouse model for chronic cerebral hypoperfusion.
Title: CCL21/CCR7 axis regulates demyelination and vascular cognitive impairment in a mouse model for chronic cerebral hypoperfusion.
Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes.
Title: Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected inflammatory monocytes.
Exacerbation of non-steroidal anti-inflammatory drug-induced enteropathy in C-C chemokine receptor type 7-deficient mice.
Title: Exacerbation of non-steroidal anti-inflammatory drug-induced enteropathy in C-C chemokine receptor type 7-deficient mice.
CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection.
Title: CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection.
CCR7 and its related molecules may be potential biomarkers of pulmonary arterial hypertension.
Title: CCR7 and its related molecules may be potential biomarkers of pulmonary arterial hypertension.
The Important Role of the Chemokine Axis CCR7-CCL19 and CCR7-CCL21 in the Pathophysiology of the Immuno-inflammatory Response in Dry Eye Disease.
Title: The Important Role of the Chemokine Axis CCR7-CCL19 and CCR7-CCL21 in the Pathophysiology of the Immuno-inflammatory Response in Dry Eye Disease.
Photochemical internalization (PCI)-mediated activation of CD8 T cells involves antigen uptake and CCR7-mediated transport by migratory dendritic cells to draining lymph nodes.
Title: Photochemical internalization (PCI)-mediated activation of CD8 T cells involves antigen uptake and CCR7-mediated transport by migratory dendritic cells to draining lymph nodes.
PU.1 regulates Ccr7 gene expression by binding to its promoter in naive CD4(+) T cells.
Title: PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4(+) T cells.

Submit: New GeneRIF Correction See all GeneRIFs (174)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (4) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ccr7 (e-PCR), detects polymorphism
- UniSTS:495963

Ccr7 (e-PCR), detects polymorphism
- UniSTS:463200

PMC321570P11 (e-PCR)
- UniSTS:273114

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables C-C motif chemokine 19 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C motif chemokine 19 receptor activity	ISO Inferred from Sequence Orthology more info
enables C-C motif chemokine 21 receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables chemokine (C-C motif) ligand 19 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 19 binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 21 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 21 binding	ISO Inferred from Sequence Orthology more info
enables chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of T cell polarity	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in lymph node development	TAS Traceable Author Statement more info	PubMed
involved_in lymphocyte chemotaxis across high endothelial venule	TAS Traceable Author Statement more info	PubMed
involved_in lymphocyte migration into lymph node	TAS Traceable Author Statement more info	PubMed
involved_in mature conventional dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of leukocyte apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IC Inferred by Curator more info	PubMed
acts_upstream_of positive regulation of JUN kinase activity	IC Inferred by Curator more info	PubMed
involved_in positive regulation of T cell chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of T cell costimulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T-helper 1 cell differentiation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of cell motility	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic cell antigen processing and presentation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IC Inferred by Curator more info	PubMed
involved_in positive regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage chemotaxis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	IC Inferred by Curator more info	PubMed
involved_in positive regulation of thymocyte migration	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IC Inferred by Curator more info	PubMed
involved_in regulation of dendritic cell dendrite assembly	IC Inferred by Curator more info	PubMed
involved_in regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tolerance induction to self antigen	TAS Traceable Author Statement more info	PubMed
involved_in regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nitric oxide	TAS Traceable Author Statement more info	PubMed
involved_in response to prostaglandin E	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor type 7

Names: EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; epstein-Barr virus-induced G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301713.1 → NP_001288642.1 C-C chemokine receptor type 7 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.

Source sequence(s)

AK037965, BF020112, BY194318

UniProtKB/TrEMBL

Q3U3J0

Conserved Domains (1) summary

pfam00001
Location:12 → 263

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_007719.2 → NP_031745.2 C-C chemokine receptor type 7 isoform a precursor

See identical proteins and their annotated locations for NP_031745.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK037965, BF020112

Consensus CDS

CCDS25373.1

UniProtKB/Swiss-Prot

P47774, Q8CAS2

UniProtKB/TrEMBL

Q3U3J0

Related

ENSMUSP00000099423.4, ENSMUST00000103134.4

Conserved Domains (1) summary

pfam00001
Location:75 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)