Ccr1l1 C-C motif chemokine receptor 1 like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccr1l1provided by MGI
Official Full Name: C-C motif chemokine receptor 1 like 1provided by MGI
Primary source: MGI:MGI:104617
See related: Ensembl:ENSMUSG00000064039 AllianceGenome:MGI:104617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cmkbr1l1
Summary: Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of monocyte chemotaxis; and positive regulation of osteoclast differentiation. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif chemokine receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 9 F4; 9 75.05 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (123776467..123786752, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (123976430..123986715, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural and functional analysis of Ccr1l1, a Rodentia-restricted eosinophil-selective chemokine receptor homologue.
Title: Structural and functional analysis of Ccr1l1, a Rodentia-restricted eosinophil-selective chemokine receptor homologue.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

UniSTS:496023 (e-PCR)
- UniSTS:496023

Ccr1l1 (e-PCR), detects polymorphism
- UniSTS:496023

NoName (e-PCR)
- UniSTS:490684

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables chemokine (C-C motif) ligand 5 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 5 binding	ISO Inferred from Sequence Orthology more info
enables chemokine (C-C motif) ligand 7 binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine (C-C motif) ligand 7 binding	ISO Inferred from Sequence Orthology more info
enables chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor 1-like protein 1

Names: MIP-1 alphaRL1; chemokine (C-C motif) receptor 1-like 1; chemokine (C-C) receptor 1-like 1; macrophage inflammatory protein-1 alpha receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.