Ckm creatine kinase, muscle [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ckmprovided by MGI
Official Full Name: creatine kinase, muscleprovided by MGI
Primary source: MGI:MGI:88413
See related: Ensembl:ENSMUSG00000030399 AllianceGenome:MGI:88413
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MCK; Ckmm; M-CK; CPK-M
Summary: Enables creatine kinase activity. Acts upstream of or within phosphocreatine biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; musculature; and sensory organ. Orthologous to human CKM (creatine kinase, M-type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 1720.2), heart adult (RPKM 1524.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.67 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19145019..19155508)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19411094..19421583)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure.
Title: Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure.
CKM is a very unique PA-binding protein that possesses exceedingly high affinity for PA, exceptional preference for SFA/MUFA-PA and extremely high specificity to PA. SFA/MUFA-PAs produced by DGKdelta are novel regulators of CKM function.
Title: Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids.
We conclude that ILK negatively and independently of PI3K regulated MEF2C phosphorylation activity and MCK mRNA expression in C2C12 cells
Title: Activated Integrin-Linked Kinase Negatively Regulates Muscle Cell Enhancement Factor 2C in C2C12 Cells.
The Fxn KO/Mck mice tested from one to two months of age showed abnormal gait patterns accompanied by a loss in motor skills.
Title: Sensorimotor skills in Fxn KO/Mck mutants deficient for frataxin in muscle.
PI3K and AKT regulated skeletal muscle differentiation by regulating the expression of Myogenin and MCK.
Title: [Expression of Myogenin and MCK genes regulated by PI3K/AKT pathway].
CK-M overexpression led to significantly increased contractile function at baseline and during adrenergic stimulation and increased survival after thoracic aortic constriction-induced heart failure.
Title: Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.
strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin and desmin
Title: Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy.
These studies indicate that the age-associated oxidative and nitrative modification of CKm results in a decrease in its activity and may cause structural changes that promote oligomerization and aggregation.
Title: Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle.
Creatine kinase (CK) and adenylate kinase (AK) are especially important in facilitating energy metabolism during very high energy demands.
Title: Gated dynamic 31P MRS shows reduced contractile phosphocreatine breakdown in mice deficient in cytosolic creatine kinase and adenylate kinase.
Dec proteins repressed a MyoD-activated promoter activity of muscle creatine kinase gene through class A E-box in an HDAC1-independent manner.
Title: Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ckmm (e-PCR), detects polymorphism
- UniSTS:141345

Ckmm (e-PCR), detects polymorphism
- UniSTS:141346

Ckm (e-PCR), detects polymorphism
- UniSTS:472873

Ckmm (e-PCR), detects polymorphism
- UniSTS:238130

RH94390 (e-PCR)
- UniSTS:119638

X03233 (e-PCR)
- UniSTS:159603

PMC125755P1 (e-PCR)
- UniSTS:270514

AI324268 (e-PCR)
- UniSTS:208083

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables creatine kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphocreatine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphocreatine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphocreatine metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: creatine kinase M-type

Names: creatine kinase M chain; creatine phosphokinase M-type

NP_031736.1

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007710.2 → NP_031736.1 creatine kinase M-type

See identical proteins and their annotated locations for NP_031736.1

Status: VALIDATED

Source sequence(s)

AC118017

Consensus CDS

CCDS20902.1

UniProtKB/Swiss-Prot

P07310

UniProtKB/TrEMBL

A2RTA0, Q9D6U7

Related

ENSMUSP00000146972.2, ENSMUST00000208710.2

Conserved Domains (1) summary

cd00716
Location:16 → 373

creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes