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    Cish cytokine inducible SH2-containing protein [ Mus musculus (house mouse) ]

    Gene ID: 12700, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cishprovided by MGI
    Official Full Name
    cytokine inducible SH2-containing proteinprovided by MGI
    Primary source
    MGI:MGI:103159
    See related
    Ensembl:ENSMUSG00000032578 AllianceGenome:MGI:103159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cis; F17; F23; CIS1; SOCS; CIS-1
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Acts upstream of or within protein kinase C-activating G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in liver; retina; and thymus primordium. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 25.8), lung adult (RPKM 20.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 F1; 9 57.99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107173858..107179983)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107296659..107302784)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase-activated protein kinase 3 Neighboring gene STARR-seq mESC enhancer starr_25168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107192213-107192396 Neighboring gene STARR-positive B cell enhancer mm9_chr9:107198795-107199096 Neighboring gene predicted gene 17040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107215338-107215525 Neighboring gene STARR-seq mESC enhancer starr_25171 Neighboring gene HemK methyltransferase family member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107240678-107240861 Neighboring gene RIKEN cDNA 6430571L13 gene Neighboring gene STARR-positive B cell enhancer ABC_E6801 Neighboring gene RIKEN cDNA 4930429P21 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity. Bernard PL, et al. J Immunother Cancer, 2022 May. PMID 35589278, Free PMC Article
    2. Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance. Palmer DC, et al. J Exp Med, 2015 Nov 16. PMID 26527801, Free PMC Article
    3. CISH is induced during DC development and regulates DC-mediated CTL activation. Miah MA, et al. Eur J Immunol, 2012 Jan. PMID 22002016
    4. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Matsumoto A, et al. Mol Cell Biol, 1999 Sep. PMID 10454585, Free PMC Article
    5. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Matsumoto A, et al. Blood, 1997 May 1. PMID 9129017

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis.
      Title: Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis.
    2. The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH) in the Regulation of Basal and Cytokine-Mediated Myelopoiesis.
      Title: The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH) in the Regulation of Basal and Cytokine-Mediated Myelopoiesis.
    3. Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB).
      Title: Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB).
    4. Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity.
      Title: Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity.
    5. Cytokine-inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism.
      Title: Cytokine-inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism.
    6. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
      Title: CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.
    7. NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.
      Title: NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.
    8. NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.
      Title: NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.
    9. Socs3 and Cish inversely regulated (increased and decreased, respectively) by bromodomain and extraterminal protein inhibition
      Title: Bromodomain and Extraterminal Inhibition by JQ1 Produces Divergent Transcriptional Regulation of Suppressors of Cytokine Signaling Genes in Adipocytes.
    10. We conclude that the Cish-SH2 domain is essential for PLC-gamma1 regulation in TCR-stimulated CD8(+) T cells.
      Title: The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein kinase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytokine-inducible SH2-containing protein
    Names
    cytokine-inducible SH2 protein
    suppressor of cytokine signaling

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317354.1 → NP_001304283.1  cytokine-inducible SH2-containing protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a distinct 5' UTR, and translation initiation from a down stream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK077338, AK086040, AL672070
      UniProtKB/TrEMBL
      Q8C3F4
      Conserved Domains (2) summary
      cl02533
      Location:119 → 159
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl15255
      Location:1 → 66
      SH2; Src homology 2 (SH2) domain

    2. NM_009895.4 → NP_034025.1  cytokine-inducible SH2-containing protein isoform 1

      See identical proteins and their annotated locations for NP_034025.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK077338, AK086040, AL672070
      Consensus CDS
      CCDS40761.1
      UniProtKB/Swiss-Prot
      Q3TC70, Q62225
      Related
      ENSMUSP00000082183.6, ENSMUST00000085102.6
      Conserved Domains (2) summary
      cd10718
      Location:77 → 164
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:217 → 257
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107173858..107179983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511635.3 → XP_006511698.1  cytokine-inducible SH2-containing protein isoform X1

      Conserved Domains (2) summary
      cd10718
      Location:145 → 232
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:285 → 325
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62225.1 GenPept UniProtKB/Swiss-Prot:Q62225

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