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    Chrm4 cholinergic receptor, muscarinic 4 [ Mus musculus (house mouse) ]

    Gene ID: 12672, updated on 21-Apr-2024

    Summary

    Official Symbol
    Chrm4provided by MGI
    Official Full Name
    cholinergic receptor, muscarinic 4provided by MGI
    Primary source
    MGI:MGI:88399
    See related
    Ensembl:ENSMUSG00000040495 AllianceGenome:MGI:88399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M4; Chrm-4; AChR M4; mm4 mAChR
    Summary
    Enables G protein-coupled acetylcholine receptor activity. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway. Located in membrane. Is expressed in several structures, including alimentary system; eye; limb; nervous system; and reproductive system. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 11.8), testis adult (RPKM 10.1) and 6 other tissues See more
    Orthologs
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    Genomic context

    Location:
    2 E1; 2 50.63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91752531..91760180)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91922189..91929835)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05122 Neighboring gene harbinger transposase derived 1 Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene Neighboring gene autophagy/beclin 1 regulator 1 Neighboring gene STARR-seq mESC enhancer starr_05123 Neighboring gene predicted gene, 39876 Neighboring gene diacylglycerol kinase zeta Neighboring gene midkine Neighboring gene microRNA 6999

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M4
    Names
    muscarinic acetylcholine receptor 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416938.1NP_001403867.1  muscarinic acetylcholine receptor M4

      Status: VALIDATED

      Source sequence(s)
      AL731772
      UniProtKB/Swiss-Prot
      P32211, Q64056
      UniProtKB/TrEMBL
      Q0VBU3
    2. NM_007699.3NP_031725.1  muscarinic acetylcholine receptor M4

      See identical proteins and their annotated locations for NP_031725.1

      Status: VALIDATED

      Source sequence(s)
      AL731772
      Consensus CDS
      CCDS16439.1
      UniProtKB/Swiss-Prot
      P32211, Q64056
      UniProtKB/TrEMBL
      Q0VBU3
      Related
      ENSMUSP00000040808.4, ENSMUST00000045537.4
      Conserved Domains (2) summary
      pfam00001
      Location:48453
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40172
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91752531..91760180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)